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Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Zizak M, et al. Among authors: donowitz m. J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27. J Biol Chem. 2012. PMID: 22371496 Free PMC article.
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M. Yang J, et al. Among authors: donowitz m. J Biol Chem. 2013 Jun 7;288(23):16960-16974. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23. J Biol Chem. 2013. PMID: 23612977 Free PMC article.
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.
Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Murtazina R, et al. Among authors: donowitz m. J Biol Chem. 2007 Aug 24;282(34):25141-51. doi: 10.1074/jbc.M701910200. Epub 2007 Jun 19. J Biol Chem. 2007. PMID: 17580307 Free article.
325 results