Hara T - Search Results

1

Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline.

Hara T, Nakamura K, Araki H, Kusaka M, Yamaoka M. Hara T, et al. Cancer Res. 2003 Sep 1;63(17):5622-8. Cancer Res. 2003. PMID: 14500404

2

Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

Hara T, Miyazaki J, Araki H, Yamaoka M, Kanzaki N, Kusaka M, Miyamoto M. Hara T, et al. Cancer Res. 2003 Jan 1;63(1):149-53. Cancer Res. 2003. PMID: 12517791

3

Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells.

Hara T, Kouno J, Nakamura K, Kusaka M, Yamaoka M. Hara T, et al. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282. Prostate. 2005. PMID: 16015592

4

A mutation in beta-tubulin and a sustained dependence on androgen receptor signalling in a newly established docetaxel-resistant prostate cancer cell line.

Hara T, Ushio K, Nishiwaki M, Kouno J, Araki H, Hikichi Y, Hattori M, Imai Y, Yamaoka M. Hara T, et al. Cell Biol Int. 2010 Jan 25;34(2):177-84. doi: 10.1042/CBI20090030. Cell Biol Int. 2010. PMID: 19947927

5

Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer.

Yamaoka M, Hara T, Kusaka M. Yamaoka M, et al. Among authors: hara t. Clin Cancer Res. 2010 Sep 1;16(17):4319-24. doi: 10.1158/1078-0432.CCR-10-0255. Epub 2010 Jul 20. Clin Cancer Res. 2010. PMID: 20647476 Review.

6

Suppression of a pituitary-ovarian axis by chronic oral administration of a novel nonpeptide gonadotropin-releasing hormone antagonist, TAK-013, in cynomolgus monkeys.

Hara T, Araki H, Kusaka M, Harada M, Cho N, Suzuki N, Furuya S, Fujino M. Hara T, et al. J Clin Endocrinol Metab. 2003 Apr;88(4):1697-704. doi: 10.1210/jc.2002-021065. J Clin Endocrinol Metab. 2003. PMID: 12679460

7

C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors.

Matsunaga N, Kaku T, Ojida A, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: hara t. Bioorg Med Chem. 2004 Aug 15;12(16):4313-36. doi: 10.1016/j.bmc.2004.06.016. Bioorg Med Chem. 2004. PMID: 15265485

8

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.

Yamamoto S, Matsunaga N, Hitaka T, Yamada M, Hara T, Miyazaki J, Santou T, Kusaka M, Yamaoka M, Kanzaki N, Furuya S, Tasaka A, Hamamura K, Ito M. Yamamoto S, et al. Among authors: hara t. Bioorg Med Chem. 2012 Jan 1;20(1):422-34. doi: 10.1016/j.bmc.2011.10.067. Epub 2011 Oct 28. Bioorg Med Chem. 2012. PMID: 22094279

9

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.

Yamaoka M, Hara T, Hitaka T, Kaku T, Takeuchi T, Takahashi J, Asahi S, Miki H, Tasaka A, Kusaka M. Yamaoka M, et al. Among authors: hara t. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28. doi: 10.1016/j.jsbmb.2012.01.001. Epub 2012 Jan 12. J Steroid Biochem Mol Biol. 2012. PMID: 22249003

10

Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists.

Yamamoto S, Tomita N, Suzuki Y, Suzaki T, Kaku T, Hara T, Yamaoka M, Kanzaki N, Hasuoka A, Baba A, Ito M. Yamamoto S, et al. Among authors: hara t. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52. doi: 10.1016/j.bmc.2012.02.005. Epub 2012 Feb 10. Bioorg Med Chem. 2012. PMID: 22391033

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