Curran KJ - Search Results

1

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties.

Di Grandi MJ, Curran KJ, Baum EZ, Bebernitz G, Ellestad GA, Ding WD, Lang SA, Rossi M, Bloom JD. Di Grandi MJ, et al. Among authors: curran kj. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3483-6. doi: 10.1016/s0960-894x(03)00789-3. Bioorg Med Chem Lett. 2003. PMID: 14505653

2

Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.

Bloom JD, DiGrandi MJ, Dushin RG, Curran KJ, Ross AA, Norton EB, Terefenko E, Jones TR, Feld B, Lang SA. Bloom JD, et al. Among authors: curran kj. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2929-32. doi: 10.1016/s0960-894x(03)00586-9. Bioorg Med Chem Lett. 2003. PMID: 14611860

3

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.

Bloom JD, Dushin RG, Curran KJ, Donahue F, Norton EB, Terefenko E, Jones TR, Ross AA, Feld B, Lang SA, DiGrandi MJ. Bloom JD, et al. Among authors: curran kj. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3401-6. doi: 10.1016/j.bmcl.2004.04.093. Bioorg Med Chem Lett. 2004. PMID: 15177441

4

Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.

Di Grandi MJ, Curran KJ, Feigelson G, Prashad A, Ross AA, Visalli R, Fairhurst J, Feld B, Bloom JD. Di Grandi MJ, et al. Among authors: curran kj. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4157-60. doi: 10.1016/j.bmcl.2004.06.025. Bioorg Med Chem Lett. 2004. PMID: 15261261

5

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J. Nittoli T, et al. J Med Chem. 2007 May 3;50(9):2108-16. doi: 10.1021/jm061428x. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402724

6

Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication.

Visalli RJ, Fairhurst J, Srinivas S, Hu W, Feld B, DiGrandi M, Curran K, Ross A, Bloom JD, van Zeijl M, Jones TR, O'Connell J, Cohen JI. Visalli RJ, et al. J Virol. 2003 Feb;77(4):2349-58. doi: 10.1128/jvi.77.4.2349-2358.2003. J Virol. 2003. PMID: 12551972 Free PMC article.

7

Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.

Verheijen JC, Richard DJ, Curran K, Kaplan J, Lefever M, Nowak P, Malwitz DJ, Brooijmans N, Toral-Barza L, Zhang WG, Lucas J, Hollander I, Ayral-Kaloustian S, Mansour TS, Yu K, Zask A. Verheijen JC, et al. J Med Chem. 2009 Dec 24;52(24):8010-24. doi: 10.1021/jm9013828. J Med Chem. 2009. PMID: 19894727

8

Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stability.

Richard DJ, Verheijen JC, Curran K, Kaplan J, Toral-Barza L, Hollander I, Lucas J, Yu K, Zask A. Richard DJ, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6830-5. doi: 10.1016/j.bmcl.2009.10.096. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2009. PMID: 19896845

9

2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: optimization of human microsomal stability.

Verheijen JC, Richard DJ, Curran K, Kaplan J, Yu K, Zask A. Verheijen JC, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2648-53. doi: 10.1016/j.bmcl.2010.02.031. Epub 2010 Feb 11. Bioorg Med Chem Lett. 2010. PMID: 20223663

10

Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.

Nowak P, Cole DC, Brooijmans N, Bursavich MG, Curran KJ, Ellingboe JW, Gibbons JJ, Hollander I, Hu Y, Kaplan J, Malwitz DJ, Toral-Barza L, Verheijen JC, Zask A, Zhang WG, Yu K. Nowak P, et al. Among authors: curran kj. J Med Chem. 2009 Nov 26;52(22):7081-9. doi: 10.1021/jm9012642. J Med Chem. 2009. PMID: 19848404

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