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Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization.
Doan T, Herd KA, Lambert PF, Fernando GJ, Street MD, Tindle RW. Doan T, et al. Cancer Res. 2000 Jun 1;60(11):2810-5. Cancer Res. 2000. PMID: 10850419
We previously have shown in mice transgenic for the E7 gene driven off an epithelial specific (keratin-14) promoter, that expression of E7 protein in peripheral epithelium is sufficient to tolerize E7-directed CTL precursors (pCTL; Doan et al, J. Virol., 73: 6166-1670, 199 …
We previously have shown in mice transgenic for the E7 gene driven off an epithelial specific (keratin-14) promoter, that expression of E7 p …
Nonspecific down-regulation of CD8+ T-cell responses in mice expressing human papillomavirus type 16 E7 oncoprotein from the keratin-14 promoter.
Tindle RW, Herd K, Doan T, Bryson G, Leggatt GR, Lambert P, Frazer IH, Street M. Tindle RW, et al. Among authors: doan t. J Virol. 2001 Jul;75(13):5985-97. doi: 10.1128/JVI.75.13.5985-5997.2001. J Virol. 2001. PMID: 11390600 Free PMC article.
Down-regulation did not involve deletion of CD8+ T cells of high affinity or high avidity, and T-cell receptor (TCR) Vbeta-chain usage and TCR receptor density were similar in antigen-responsive cells from E7 transgenic and non-E7 transgenic mice. ...We have previou …
Down-regulation did not involve deletion of CD8+ T cells of high affinity or high avidity, and T-cell receptor (TCR) Vbeta-cha …
Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibility complex class I alleles.
Doan T, Herd K, Street M, Bryson G, Fernando G, Lambert P, Tindle R. Doan T, et al. J Virol. 1999 Jul;73(7):6166-70. doi: 10.1128/JVI.73.7.6166-6170.1999. J Virol. 1999. PMID: 10364377 Free PMC article.
Mice which coexpress human papillomavirus type 16 E7 and HLA A2.1 in peripheral squamous epithelium and thymic cortical epithelium are tolerant at the cytotoxic T-lymphocyte (CTL) level to E7 epitopes restricted through HLA A*0201 and H-2(b) (T. Doan, M. Cham …
Mice which coexpress human papillomavirus type 16 E7 and HLA A2.1 in peripheral squamous epithelium and thymic cortical epithelium are toler …
1,083 results