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Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
Métifiot M, Johnson BC, Kiselev E, Marler L, Zhao XZ, Burke TR Jr, Marchand C, Hughes SH, Pommier Y. Métifiot M, et al. Among authors: marchand c. Nucleic Acids Res. 2016 Aug 19;44(14):6896-906. doi: 10.1093/nar/gkw592. Epub 2016 Jul 1. Nucleic Acids Res. 2016. PMID: 27369381 Free PMC article.
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
Antony S, Marchand C, Stephen AG, Thibaut L, Agama KK, Fisher RJ, Pommier Y. Antony S, et al. Among authors: marchand c. Nucleic Acids Res. 2007;35(13):4474-84. doi: 10.1093/nar/gkm463. Epub 2007 Jun 18. Nucleic Acids Res. 2007. PMID: 17576665 Free PMC article.
Repair of topoisomerase I-mediated DNA damage.
Pommier Y, Barcelo JM, Rao VA, Sordet O, Jobson AG, Thibaut L, Miao ZH, Seiler JA, Zhang H, Marchand C, Agama K, Nitiss JL, Redon C. Pommier Y, et al. Among authors: marchand c. Prog Nucleic Acid Res Mol Biol. 2006;81:179-229. doi: 10.1016/S0079-6603(06)81005-6. Prog Nucleic Acid Res Mol Biol. 2006. PMID: 16891172 Free PMC article. Review.
507 results