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Page 1
Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.
Ueda Y, Matiskella JD, Golik J, Connolly TP, Hudyma TW, Venkatesh S, Dali M, Kang SH, Barbour N, Tejwani R, Varia S, Knipe J, Zheng M, Mathew M, Mosure K, Clark J, Lamb L, Medin I, Gao Q, Huang S, Chen CP, Bronson JJ. Ueda Y, et al. Among authors: connolly tp. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3669-72. doi: 10.1016/j.bmcl.2003.08.029. Bioorg Med Chem Lett. 2003. PMID: 14552754
Synthesis and antibacterial activity of nocathiacin I analogues.
Naidu BN, Sorenson ME, Matiskella JD, Li W, Sausker JB, Zhang Y, Connolly TP, Lam KS, Bronson JJ, Pucci MJ, Yang H, Ueda Y. Naidu BN, et al. Among authors: connolly tp. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3545-9. doi: 10.1016/j.bmcl.2006.03.079. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621551
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043).
Kadow JF, Ueda Y, Meanwell NA, Connolly TP, Wang T, Chen CP, Yeung KS, Zhu J, Bender JA, Yang Z, Parker D, Lin PF, Colonno RJ, Mathew M, Morgan D, Zheng M, Chien C, Grasela D. Kadow JF, et al. Among authors: connolly tp. J Med Chem. 2012 Mar 8;55(5):2048-56. doi: 10.1021/jm201218m. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22356441 Clinical Trial.
Synthesis and activity of a C-8 keto pleuromutilin derivative.
Springer DM, Sorenson ME, Huang S, Connolly TP, Bronson JJ, Matson JA, Hanson RL, Brzozowski DB, LaPorte TL, Patel RN. Springer DM, et al. Among authors: connolly tp. Bioorg Med Chem Lett. 2003 May 19;13(10):1751-3. doi: 10.1016/s0960-894x(03)00297-x. Bioorg Med Chem Lett. 2003. PMID: 12729657
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Naidu BN, Walker MA, Sorenson ME, Ueda Y, Matiskella JD, Connolly TP, Dicker IB, Lin Z, Bollini S, Terry BJ, Higley H, Zheng M, Parker DD, Wu D, Adams S, Krystal MR, Meanwell NA. Naidu BN, et al. Among authors: connolly tp. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2124-2130. doi: 10.1016/j.bmcl.2018.05.027. Epub 2018 May 14. Bioorg Med Chem Lett. 2018. PMID: 29779976
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Sivaprakasam P, Wang Z, Meanwell NA, Khan JA, Langley DR, Johnson SR, Li G, Pendri A, Connolly TP, Gao M, Camac DM, Klakouski C, Zvyaga T, Cianci C, McAuliffe B, Ding B, Discotto L, Krystal MR, Jenkins S, Peese KM, Narasimhulu Naidu B. Sivaprakasam P, et al. Among authors: connolly tp. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127531. doi: 10.1016/j.bmcl.2020.127531. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890685
34 results