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Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. Koleske ML, et al. Among authors: schlessinger a. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2210247119. doi: 10.1073/pnas.2210247119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343260 Free PMC article.
Conserved allosteric inhibition mechanism in SLC1 transporters.
Dong Y, Wang J, Garibsingh RA, Hutchinson K, Shi Y, Eisenberg G, Yu X, Schlessinger A, Grewer C. Dong Y, et al. Among authors: schlessinger a. Elife. 2023 Mar 1;12:e83464. doi: 10.7554/eLife.83464. Elife. 2023. PMID: 36856089 Free PMC article.
Substrate binding and inhibition of the anion exchanger 1 transporter.
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D. Capper MJ, et al. Among authors: schlessinger a. Nat Struct Mol Biol. 2023 Oct;30(10):1495-1504. doi: 10.1038/s41594-023-01085-6. Epub 2023 Sep 7. Nat Struct Mol Biol. 2023. PMID: 37679563 Free PMC article.
Natively unstructured loops differ from other loops.
Schlessinger A, Liu J, Rost B. Schlessinger A, et al. PLoS Comput Biol. 2007 Jul;3(7):e140. doi: 10.1371/journal.pcbi.0030140. PLoS Comput Biol. 2007. PMID: 17658943 Free PMC article.
115 results