Workman P - Search Results

1

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Seddon BM, Payne GS, Simmons L, Ruddle R, Grimshaw R, Tan S, Turner A, Raynaud F, Halbert G, Leach MO, Judson I, Workman P. Seddon BM, et al. Among authors: workman p. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. Clin Cancer Res. 2003. PMID: 14613987 Review.

2

Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.

Aboagye EO, Maxwell RJ, Kelson AB, Tracy M, Lewis AD, Graham MA, Horsman MR, Griffiths JR, Workman P. Aboagye EO, et al. Among authors: workman p. Cancer Res. 1997 Aug 1;57(15):3314-8. Cancer Res. 1997. PMID: 9242466

3

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.

Aboagye EO, Maxwell RJ, Horsman MR, Lewis AD, Workman P, Tracy M, Griffiths JR. Aboagye EO, et al. Among authors: workman p. Br J Cancer. 1998;77(1):65-70. doi: 10.1038/bjc.1998.10. Br J Cancer. 1998. PMID: 9459147 Free PMC article.

4

Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks.

Senan S, Rampling R, Graham MA, Wilson P, Robin H Jr, Eckardt N, Lawson N, McDonald A, von Roemeling R, Workman P, Kaye SB. Senan S, et al. Among authors: workman p. Clin Cancer Res. 1997 Jan;3(1):31-8. Clin Cancer Res. 1997. PMID: 9815534 Clinical Trial.

5

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I, Workman P. Clarke PA, et al. Among authors: workman p. Oncogene. 2000 Aug 24;19(36):4125-33. doi: 10.1038/sj.onc.1203753. Oncogene. 2000. PMID: 10962573

6

Measurement of tumor oxygenation: in vivo comparison of a luminescence fiber-optic sensor and a polarographic electrode in the p22 tumor.

Seddon BM, Honess DJ, Vojnovic B, Tozer GM, Workman P. Seddon BM, et al. Among authors: workman p. Radiat Res. 2001 Jun;155(6):837-46. doi: 10.1667/0033-7587(2001)155[0837:motoiv]2.0.co;2. Radiat Res. 2001. PMID: 11352767

7

Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.

Smith V, Raynaud F, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Mol Pharmacol. 2001 Nov;60(5):885-93. doi: 10.1124/mol.60.5.885. Mol Pharmacol. 2001. PMID: 11641415

8

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Kelland LR, et al. Among authors: workman p. Clin Cancer Res. 2001 Nov;7(11):3544-50. Clin Cancer Res. 2001. PMID: 11705875

9

Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques.

Anderson H, Price P, Blomley M, Leach MO, Workman P; Cancer Research Campaign PK/PD Technologies Advisory Committee. Anderson H, et al. Among authors: workman p. Br J Cancer. 2001 Oct 19;85(8):1085-93. doi: 10.1054/bjoc.2001.2077. Br J Cancer. 2001. PMID: 11710817 Free PMC article.

10

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.

Smith V, Rowlands MG, Barrie E, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Clin Cancer Res. 2002 Jun;8(6):2002-9. Clin Cancer Res. 2002. PMID: 12060646

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