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Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways.
Dai C, Zhang Y, Gong Y, Bradley A, Tang Z, Sellick K, Shrestha S, Spears E, Covington BA, Stanley J, Jenkins R, Richardson TM, Brantley RA, Coate K, Saunders DC, Wright JJ, Brissova M, Dean ED, Powers AC, Chen W. Dai C, et al. Among authors: spears e. iScience. 2024 Nov 22;27(12):111447. doi: 10.1016/j.isci.2024.111447. eCollection 2024 Dec 20. iScience. 2024. PMID: 39720531 Free PMC article.
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Coate KC, et al. Among authors: spears e. Mol Metab. 2024 Dec;90:102050. doi: 10.1016/j.molmet.2024.102050. Epub 2024 Oct 20. Mol Metab. 2024. PMID: 39433176 Free PMC article.
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Spears E, Poffenberger G, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Coate KC, et al. Among authors: spears e. bioRxiv [Preprint]. 2024 Aug 7:2024.08.06.606926. doi: 10.1101/2024.08.06.606926. bioRxiv. 2024. Update in: Mol Metab. 2024 Dec;90:102050. doi: 10.1016/j.molmet.2024.102050 PMID: 39149351 Free PMC article. Updated. Preprint.
40 results