Zhang R - Search Results

1

Application of the lambda-dynamics method to evaluate the relative binding free energies of inhibitors to HCV protease.

Guo Z, Durkin J, Fischmann T, Ingram R, Prongay A, Zhang R, Madison V. Guo Z, et al. Among authors: zhang r. J Med Chem. 2003 Dec 4;46(25):5360-4. doi: 10.1021/jm030040o. J Med Chem. 2003. PMID: 14640544

2

Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease.

Zhang R, Durkin JP, Windsor WT. Zhang R, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1005-8. doi: 10.1016/s0960-894x(02)00102-6. Bioorg Med Chem Lett. 2002. PMID: 11909704

3

Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction.

Zhang R, Mayhood T, Lipari P, Wang Y, Durkin J, Syto R, Gesell J, McNemar C, Windsor W. Zhang R, et al. Anal Biochem. 2004 Aug 1;331(1):138-46. doi: 10.1016/j.ab.2004.03.009. Anal Biochem. 2004. PMID: 15246006

4

ADAM33 enzyme properties and substrate specificity.

Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP. Zou J, et al. Among authors: zhang r. Biochemistry. 2005 Mar 22;44(11):4247-56. doi: 10.1021/bi0476230. Biochemistry. 2005. PMID: 15766253

5

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Prongay AJ, et al. Among authors: zhang r. J Med Chem. 2007 May 17;50(10):2310-8. doi: 10.1021/jm060173k. Epub 2007 Apr 20. J Med Chem. 2007. PMID: 17444623

6

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.

Madison V, Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG. Madison V, et al. Among authors: zhang r. J Synchrotron Radiat. 2008 May;15(Pt 3):204-7. doi: 10.1107/S0909049507064229. Epub 2008 Apr 18. J Synchrotron Radiat. 2008. PMID: 18421139 Free PMC article.

7

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.

Deng Y, Shipps GW Jr, Zhao L, Siddiqui MA, Popovici-Muller J, Curran PJ, Duca JS, Hruza AW, Fischmann TO, Madison VS, Zhang R, McNemar CW, Mayhood TW, Syto R, Annis A, Kirschmeier P, Lees EM, Parry DA, Windsor WT. Deng Y, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2014 Jan 1;24(1):199-203. doi: 10.1016/j.bmcl.2013.11.041. Epub 2013 Nov 23. Bioorg Med Chem Lett. 2014. PMID: 24332088

8

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

McKittrick BA, Caldwell JP, Bara T, Boykow G, Chintala M, Clader J, Czarniecki M, Courneya B, Duffy R, Fleming L, Giessert R, Greenlee WJ, Heap C, Hong L, Huang Y, Iserloh U, Josien H, Khan T, Korfmacher W, Liang X, Mazzola R, Mitra S, Moore K, Orth P, Rajagopalan M, Roy S, Sakwa S, Strickland C, Vaccaro H, Voigt J, Wang H, Wong J, Zhang R, Zych A. McKittrick BA, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1592-6. doi: 10.1016/j.bmcl.2015.02.003. Epub 2015 Feb 10. Bioorg Med Chem Lett. 2015. PMID: 25728416

9

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Among authors: zhang r. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753

10

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.

Howe JA, Xiao L, Fischmann TO, Wang H, Tang H, Villafania A, Zhang R, Barbieri CM, Roemer T. Howe JA, et al. Among authors: zhang r. RNA Biol. 2016 Oct 2;13(10):946-954. doi: 10.1080/15476286.2016.1216304. Epub 2016 Aug 2. RNA Biol. 2016. PMID: 27485612 Free PMC article.

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