Xue CB - Search Results

1

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.

Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4293-7. doi: 10.1016/j.bmcl.2003.09.056. Bioorg Med Chem Lett. 2003. PMID: 14643312

2

Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.

Wasserman ZR, Duan JJ, Voss ME, Xue CB, Cherney RJ, Nelson DJ, Hardman KD, Decicco CP. Wasserman ZR, et al. Among authors: xue cb. Chem Biol. 2003 Mar;10(3):215-23. doi: 10.1016/s1074-5521(03)00044-9. Chem Biol. 2003. PMID: 12670535

3

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Duan JJ, Lu Z, Xue CB, He X, Seng JL, Roderick JJ, Wasserman ZR, Liu RQ, Covington MB, Magolda RL, Newton RC, Trzaskos JM, Decicco CP. Duan JJ, et al. Among authors: xue cb. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2035-40. doi: 10.1016/s0960-894x(03)00313-5. Bioorg Med Chem Lett. 2003. PMID: 12781190

4

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.

Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Qian M, Ribadeneira MD, Vaddi K, Christ DD, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4299-304. doi: 10.1016/j.bmcl.2003.09.057. Bioorg Med Chem Lett. 2003. PMID: 14643313

5

Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.

Xue CB, Chen XT, He X, Roderick J, Corbett RL, Ghavimi B, Liu RQ, Covington MB, Qian M, Ribadeneira MD, Vaddi K, Trzaskos J, Newton RC, Duan JJ, Decicco CP. Xue CB, et al. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4453-9. doi: 10.1016/j.bmcl.2004.06.049. Bioorg Med Chem Lett. 2004. PMID: 15357971

6

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Sheppeck JE 2nd, Gilmore JL, Yang A, Chen XT, Xue CB, Roderick J, Liu RQ, Covington MB, Decicco CP, Duan JJ. Sheppeck JE 2nd, et al. Among authors: xue cb. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1413-7. doi: 10.1016/j.bmcl.2006.11.089. Epub 2006 Dec 2. Bioorg Med Chem Lett. 2007. PMID: 17188863

7

A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.

Chen XT, Ghavimi B, Corbett RL, Xue CB, Liu RQ, Covington MB, Qian M, Vaddi KG, Christ DD, Hartman KD, Ribadeneira MD, Trzaskos JM, Newton RC, Decicco CP, Duan JJ. Chen XT, et al. Among authors: xue cb. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1865-70. doi: 10.1016/j.bmcl.2007.01.041. Epub 2007 Jan 24. Bioorg Med Chem Lett. 2007. PMID: 17276676

8

Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Sheppeck JE 2nd, Gilmore JL, Tebben A, Xue CB, Liu RQ, Decicco CP, Duan JJ. Sheppeck JE 2nd, et al. Among authors: xue cb. Bioorg Med Chem Lett. 2007 May 15;17(10):2769-74. doi: 10.1016/j.bmcl.2007.02.076. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17368021

9

Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.

Duan JJ, Chen L, Lu Z, Xue CB, Liu RQ, Covington MB, Qian M, Wasserman ZR, Vaddi K, Christ DD, Trzaskos JM, Newton RC, Decicco CP. Duan JJ, et al. Among authors: xue cb. Bioorg Med Chem Lett. 2008 Jan 1;18(1):241-6. doi: 10.1016/j.bmcl.2007.10.093. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18032037

10

Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2.

Xue CB, Wang A, Meloni D, Zhang K, Kong L, Feng H, Glenn J, Huang T, Zhang Y, Cao G, Anand R, Zheng C, Xia M, Han Q, Robinson DJ, Storace L, Shao L, Li M, Brodmerkel CM, Covington M, Scherle P, Diamond S, Yeleswaram S, Vaddi K, Newton R, Hollis G, Friedman S, Metcalf B. Xue CB, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7473-8. doi: 10.1016/j.bmcl.2010.10.020. Epub 2010 Oct 13. Bioorg Med Chem Lett. 2010. PMID: 21036044

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