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RWJ-58259: a selective antagonist of protease activated receptor-1.
Damiano BP, Derian CK, Maryanoff BE, Zhang HC, Gordon PA. Damiano BP, et al. Among authors: zhang hc. Cardiovasc Drug Rev. 2003 Winter;21(4):313-26. doi: 10.1111/j.1527-3466.2003.tb00124.x. Cardiovasc Drug Rev. 2003. PMID: 14647534 Review.
Therapeutic potential of protease-activated receptor-1 antagonists.
Derian CK, Maryanoff BE, Zhang HC, Andrade-Gordon P. Derian CK, et al. Among authors: zhang hc. Expert Opin Investig Drugs. 2003 Feb;12(2):209-21. doi: 10.1517/13543784.12.2.209. Expert Opin Investig Drugs. 2003. PMID: 12556215 Review.
Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Xiang MA, Rybczynski PJ, Patel M, Chen RH, McComsey DF, Zhang HC, Gunnet JW, Look R, Wang Y, Minor LK, Zhong HM, Villani FJ, Demarest KT, Damiano BP, Maryanoff BE. Xiang MA, et al. Among authors: zhang hc. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6623-8. doi: 10.1016/j.bmcl.2007.09.059. Epub 2007 Sep 19. Bioorg Med Chem Lett. 2007. PMID: 17942308
Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.
Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB. Andrade-Gordon P, et al. Among authors: zhang hc. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62. doi: 10.1073/pnas.96.22.12257. Proc Natl Acad Sci U S A. 1999. PMID: 10535908 Free PMC article.
Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.
Zhang HC, Derian CK, Andrade-Gordon P, Hoekstra WJ, McComsey DF, White KB, Poulter BL, Addo MF, Cheung WM, Damiano BP, Oksenberg D, Reynolds EE, Pandey A, Scarborough RM, Maryanoff BE. Zhang HC, et al. J Med Chem. 2001 Mar 29;44(7):1021-4. doi: 10.1021/jm000506s. J Med Chem. 2001. PMID: 11297447 No abstract available.
Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.
Andrade-Gordon P, Derian CK, Maryanoff BE, Zhang HC, Addo MF, Cheung Wm, Damiano BP, D'Andrea MR, Darrow AL, de Garavilla L, Eckardt AJ, Giardino EC, Haertlein BJ, McComsey DF. Andrade-Gordon P, et al. Among authors: zhang hc. J Pharmacol Exp Ther. 2001 Jul;298(1):34-42. J Pharmacol Exp Ther. 2001. PMID: 11408522
462 results