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Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.
Okubo Y, Siddle K, Firth H, O'Rahilly S, Wilson LC, Willatt L, Fukushima T, Takahashi S, Petry CJ, Saukkonen T, Stanhope R, Dunger DB. Okubo Y, et al. Among authors: takahashi s. J Clin Endocrinol Metab. 2003 Dec;88(12):5981-8. doi: 10.1210/jc.2002-021080. J Clin Endocrinol Metab. 2003. PMID: 14671200
Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.
Kawashima Y, Kanzaki S, Yang F, Kinoshita T, Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomoya H, Nanba E, Fukushima T, Takahashi S. Kawashima Y, et al. Among authors: takahashi s. J Clin Endocrinol Metab. 2005 Aug;90(8):4679-87. doi: 10.1210/jc.2004-1947. Epub 2005 May 31. J Clin Endocrinol Metab. 2005. PMID: 15928254
Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation.
Kawashima Y, Hakuno F, Okada S, Hotsubo T, Kinoshita T, Fujimoto M, Nishimura R, Fukushima T, Hanaki K, Takahashi S, Kanzaki S. Kawashima Y, et al. Among authors: takahashi s. Clin Endocrinol (Oxf). 2014 Aug;81(2):312-4. doi: 10.1111/cen.12317. Epub 2013 Sep 30. Clin Endocrinol (Oxf). 2014. PMID: 24033502 No abstract available.
Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.
Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: takahashi s. Endocrinology. 2008 Jul;149(7):3729-42. doi: 10.1210/en.2007-1443. Epub 2008 Apr 10. Endocrinology. 2008. PMID: 18403485
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: takahashi s. J Biol Chem. 2012 Aug 24;287(35):29713-21. doi: 10.1074/jbc.M112.393074. Epub 2012 Jul 5. J Biol Chem. 2012. PMID: 22767591 Free PMC article.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Fukushima T, Arai T, Ariga-Nedachi M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Among authors: takahashi s. Biochem Biophys Res Commun. 2011 Jan 21;404(3):767-73. doi: 10.1016/j.bbrc.2010.12.045. Epub 2010 Dec 17. Biochem Biophys Res Commun. 2011. PMID: 21168390
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