Minnikin DE - Search Results

1

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS. Senior SJ, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2004 Jan 19;14(2):373-6. doi: 10.1016/j.bmcl.2003.10.061. Bioorg Med Chem Lett. 2004. PMID: 14698162

2

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity.

Douglas JD, Senior SJ, Morehouse C, Phetsukiri B, Campbell IB, Besra GS, Minnikin DE. Douglas JD, et al. Among authors: minnikin de. Microbiology (Reading). 2002 Oct;148(Pt 10):3101-3109. doi: 10.1099/00221287-148-10-3101. Microbiology (Reading). 2002. PMID: 12368443 Free article.

3

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS. Senior SJ, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3685-8. doi: 10.1016/j.bmcl.2003.08.015. Bioorg Med Chem Lett. 2003. PMID: 14552758

4

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Guy MR, Illarionov PA, Gurcha SS, Dover LG, Gibson KJ, Smith PW, Minnikin DE, Besra GS. Guy MR, et al. Among authors: minnikin de. Biochem J. 2004 Sep 15;382(Pt 3):905-12. doi: 10.1042/BJ20040911. Biochem J. 2004. PMID: 15202931 Free PMC article.

5

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.

Bhowruth V, Brown AK, Reynolds RC, Coxon GD, Mackay SP, Minnikin DE, Besra GS. Bhowruth V, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4743-7. doi: 10.1016/j.bmcl.2006.06.095. Epub 2006 Jul 27. Bioorg Med Chem Lett. 2006. PMID: 16875817

6

The methyl-branched fortifications of Mycobacterium tuberculosis.

Minnikin DE, Kremer L, Dover LG, Besra GS. Minnikin DE, et al. Chem Biol. 2002 May;9(5):545-53. doi: 10.1016/s1074-5521(02)00142-4. Chem Biol. 2002. PMID: 12031661 Review.

7

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.

Bhatt A, Brown AK, Singh A, Minnikin DE, Besra GS. Bhatt A, et al. Among authors: minnikin de. Chem Biol. 2008 Sep 22;15(9):930-9. doi: 10.1016/j.chembiol.2008.07.007. Chem Biol. 2008. PMID: 18804030 Free PMC article.

8

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.

Bhowruth V, Minnikin DE, Agger EM, Andersen P, Bramwell VW, Perrie Y, Besra GS. Bhowruth V, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2029-32. doi: 10.1016/j.bmcl.2009.02.027. Epub 2009 Feb 11. Bioorg Med Chem Lett. 2009. PMID: 19251417

9

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.

Singh A, Varela C, Bhatt K, Veerapen N, Lee OY, Wu HH, Besra GS, Minnikin DE, Fujiwara N, Teramoto K, Bhatt A. Singh A, et al. Among authors: minnikin de. PLoS One. 2016 Oct 14;11(10):e0164253. doi: 10.1371/journal.pone.0164253. eCollection 2016. PLoS One. 2016. PMID: 27741286 Free PMC article.

10

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system.

Batt SM, Minnikin DE, Besra GS. Batt SM, et al. Among authors: minnikin de. Biochem J. 2020 May 29;477(10):1983-2006. doi: 10.1042/BCJ20200194. Biochem J. 2020. PMID: 32470138 Free PMC article. Review.

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