Multani A - Search Results

1

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.

Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. Liu G, et al. Among authors: multani a. Nat Genet. 2004 Jan;36(1):63-8. doi: 10.1038/ng1282. Epub 2003 Dec 21. Nat Genet. 2004. PMID: 14702042 Free article.

2

Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer.

Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K. Akli S, et al. Cancer Res. 2004 May 1;64(9):3198-208. doi: 10.1158/0008-5472.can-03-3672. Cancer Res. 2004. PMID: 15126360

3

Essential role of limiting telomeres in the pathogenesis of Werner syndrome.

Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Chang S, et al. Among authors: multani as. Nat Genet. 2004 Aug;36(8):877-82. doi: 10.1038/ng1389. Epub 2004 Jul 4. Nat Genet. 2004. PMID: 15235603

4

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA. Hingorani SR, et al. Among authors: multani as. Cancer Cell. 2005 May;7(5):469-83. doi: 10.1016/j.ccr.2005.04.023. Cancer Cell. 2005. PMID: 15894267 Free article.

5

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Laud PR, et al. Among authors: multani as. Genes Dev. 2005 Nov 1;19(21):2560-70. doi: 10.1101/gad.1321305. Genes Dev. 2005. PMID: 16264192 Free PMC article.

6

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.

Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, Bachilo O, Pathak S, Tahara H, Bailey SM, Deng Y, Behringer RR, Chang S. Wu L, et al. Cell. 2006 Jul 14;126(1):49-62. doi: 10.1016/j.cell.2006.05.037. Cell. 2006. PMID: 16839876 Free article.

7

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.

He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, Deng Y, Chang S. He H, et al. EMBO J. 2006 Nov 1;25(21):5180-90. doi: 10.1038/sj.emboj.7601294. Epub 2006 Oct 19. EMBO J. 2006. PMID: 17053789 Free PMC article.

8

WRN at telomeres: implications for aging and cancer.

Multani AS, Chang S. Multani AS, et al. J Cell Sci. 2007 Mar 1;120(Pt 5):713-21. doi: 10.1242/jcs.03397. J Cell Sci. 2007. PMID: 17314245 Review.

9

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence.

Cosme-Blanco W, Shen MF, Lazar AJ, Pathak S, Lozano G, Multani AS, Chang S. Cosme-Blanco W, et al. EMBO Rep. 2007 May;8(5):497-503. doi: 10.1038/sj.embor.7400937. Epub 2007 Mar 30. EMBO Rep. 2007. PMID: 17396137 Free PMC article.

10

Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway.

Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K. Akli S, et al. Cancer Res. 2007 Aug 1;67(15):7212-22. doi: 10.1158/0008-5472.CAN-07-0599. Cancer Res. 2007. PMID: 17671189

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