Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.
Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT.
Bugg TD, et al. Among authors: arthur m.
Biochemistry. 1991 Oct 29;30(43):10408-15. doi: 10.1021/bi00107a007.
Biochemistry. 1991.
PMID: 1931965
VanA is a D-alanine:D-alanine ligase of altered substrate specificity [Bugg, T. D. H., Dutka-Malen, S., Arthur, M., Courvalin, P., & Walsh, C. T. (1991) Biochemistry 30, 2017-2021], while the sequence of VanH is related to those of alpha-keto acid dehydrogenases …
VanA is a D-alanine:D-alanine ligase of altered substrate specificity [Bugg, T. D. H., Dutka-Malen, S., Arthur, M., Courvalin, …