Sausville EA - Search Results

1

Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity.

Hose CD, Hollingshead M, Sausville EA, Monks A. Hose CD, et al. Among authors: sausville ea. Mol Cancer Ther. 2003 Dec;2(12):1265-72. Mol Cancer Ther. 2003. PMID: 14707267

2

Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.

Loaiza-Pérez AI, Trapani V, Hose C, Singh SS, Trepel JB, Stevens MF, Bradshaw TD, Sausville EA. Loaiza-Pérez AI, et al. Among authors: sausville ea. Mol Pharmacol. 2002 Jan;61(1):13-9. doi: 10.1124/mol.61.1.13. Mol Pharmacol. 2002. PMID: 11752201

3

Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole.

Monks A, Harris E, Hose C, Connelly J, Sausville EA. Monks A, et al. Among authors: sausville ea. Mol Pharmacol. 2003 Mar;63(3):766-72. doi: 10.1124/mol.63.3.766. Mol Pharmacol. 2003. PMID: 12606787

4

Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.

Loaiza-Pérez AI, Kenney S, Boswell J, Hollingshead M, Alley MC, Hose C, Ciolino HP, Yeh GC, Trepel JB, Vistica DT, Sausville EA. Loaiza-Pérez AI, et al. Among authors: sausville ea. Mol Cancer Ther. 2004 Jun;3(6):715-25. Mol Cancer Ther. 2004. PMID: 15210858

5

Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.

Brantley E, Trapani V, Alley MC, Hose CD, Bradshaw TD, Stevens MF, Sausville EA, Stinson SF. Brantley E, et al. Among authors: sausville ea. Drug Metab Dispos. 2004 Dec;32(12):1392-401. doi: 10.1124/dmd.104.001057. Epub 2004 Sep 8. Drug Metab Dispos. 2004. PMID: 15355884

6

The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells.

Brantley E, Patel V, Stinson SF, Trapani V, Hose CD, Ciolino HP, Yeh GC, Gutkind JS, Sausville EA, Loaiza-Pérez AI. Brantley E, et al. Among authors: sausville ea. Anticancer Drugs. 2005 Feb;16(2):137-43. doi: 10.1097/00001813-200502000-00004. Anticancer Drugs. 2005. PMID: 15655410

7

Preclinical models for defining efficacy of drug combinations: mapping the road to the clinic.

Gitler MS, Monks A, Sausville EA. Gitler MS, et al. Among authors: sausville ea. Mol Cancer Ther. 2003 Sep;2(9):929-32. Mol Cancer Ther. 2003. PMID: 14555712 No abstract available.

8

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.

Alley MC, Hollingshead MG, Pacula-Cox CM, Waud WR, Hartley JA, Howard PW, Gregson SJ, Thurston DE, Sausville EA. Alley MC, et al. Among authors: sausville ea. Cancer Res. 2004 Sep 15;64(18):6700-6. doi: 10.1158/0008-5472.CAN-03-2942. Cancer Res. 2004. PMID: 15374987

9

Transcriptional profiling identifies altered intracellular labile iron homeostasis as a contributing factor to the toxicity of adaphostin: decreased vascular endothelial growth factor secretion is independent of hypoxia-inducible factor-1 regulation.

Hose C, Kaur G, Sausville EA, Monks A. Hose C, et al. Among authors: sausville ea. Clin Cancer Res. 2005 Sep 1;11(17):6370-81. doi: 10.1158/1078-0432.CCR-05-0291. Clin Cancer Res. 2005. PMID: 16144942

10

Differential gene expression as a potential classifier of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole-sensitive and -insensitive cell lines.

Wallqvist A, Connelly J, Sausville EA, Covell DG, Monks A. Wallqvist A, et al. Among authors: sausville ea. Mol Pharmacol. 2006 Mar;69(3):737-48. doi: 10.1124/mol.105.017061. Epub 2005 Dec 6. Mol Pharmacol. 2006. PMID: 16332985

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