Zhang L - Search Results

1

Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.

Carroll FI, Zhang L, Mascarella SW, Navarro HA, Rothman RB, Cantrell BE, Zimmerman DM, Thomas JB. Carroll FI, et al. Among authors: zhang l. J Med Chem. 2004 Jan 15;47(2):281-4. doi: 10.1021/jm030419a. J Med Chem. 2004. PMID: 14711299

2

Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.

Thomas JB, Zhang L, Navarro HA, Carroll FI. Thomas JB, et al. Among authors: zhang l. J Med Chem. 2006 Sep 7;49(18):5597-609. doi: 10.1021/jm060459p. J Med Chem. 2006. PMID: 16942033

3

Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.

Zhang L, Zhao J, Zhang B, Lu T, Chen Y. Zhang L, et al. Among authors: zhang b. Eur J Med Chem. 2018 Apr 25;150:809-816. doi: 10.1016/j.ejmech.2018.03.049. Epub 2018 Mar 21. Eur J Med Chem. 2018. PMID: 29602036

4

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation.

Li J, Chen J, Zhang L, Wang F, Gui C, Zhang L, Qin Y, Xu Q, Liu H, Nan F, Shen J, Bai D, Chen K, Shen X, Jiang H. Li J, et al. Among authors: zhang l. Bioorg Med Chem. 2006 Aug 15;14(16):5527-34. doi: 10.1016/j.bmc.2006.04.026. Epub 2006 May 6. Bioorg Med Chem. 2006. PMID: 16682211 Free PMC article.

5

Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo.

Wang LL, Kong L, Liu H, Zhang Y, Zhang L, Liu X, Yuan F, Li Y, Zuo Z. Wang LL, et al. Among authors: zhang l, zhang y. Eur J Med Chem. 2019 Nov 15;182:111665. doi: 10.1016/j.ejmech.2019.111665. Epub 2019 Aug 30. Eur J Med Chem. 2019. PMID: 31494469

6

Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.

Zhang L, Zhang B, Zhao J, Zhi Y, Wang L, Lu T, Chen Y. Zhang L, et al. Among authors: zhang b. Eur J Med Chem. 2017 Sep 29;138:942-951. doi: 10.1016/j.ejmech.2017.06.057. Epub 2017 Jun 29. Eur J Med Chem. 2017. PMID: 28755635

7

Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.

Yuan H, Liu Q, Zhang L, Hu S, Chen T, Li H, Chen Y, Xu Y, Lu T. Yuan H, et al. Among authors: zhang l. Eur J Med Chem. 2018 Jan 1;143:491-502. doi: 10.1016/j.ejmech.2017.11.073. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29202410

8

Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.

Wang Y, Zhi Y, Jin Q, Lu S, Lin G, Yuan H, Yang T, Wang Z, Yao C, Ling J, Guo H, Li T, Jin J, Li B, Zhang L, Chen Y, Lu T. Wang Y, et al. Among authors: zhang l. J Med Chem. 2018 Feb 22;61(4):1499-1518. doi: 10.1021/acs.jmedchem.7b01261. Epub 2018 Feb 12. J Med Chem. 2018. PMID: 29357250

9

New lead discovery of insect growth regulators based on the scaffold hopping strategy.

Jiang B, Guo B, Cui J, Dong Y, Cui L, Zhang L, Yang Q, Yang X. Jiang B, et al. Among authors: zhang l. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127500. doi: 10.1016/j.bmcl.2020.127500. Epub 2020 Aug 18. Bioorg Med Chem Lett. 2020. PMID: 32822762

10

Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors.

Zhang L, Zhang J, Fang H, Wang Q, Xu W. Zhang L, et al. Among authors: zhang j. Bioorg Med Chem. 2006 Dec 15;14(24):8286-94. doi: 10.1016/j.bmc.2006.09.015. Epub 2006 Sep 27. Bioorg Med Chem. 2006. PMID: 17008101

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