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Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.
Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS, Hinshaw JC, Garnier P, Prestwich GD, Leonardson A, Garrett-Engele P, Rush CM, Bard M, Schimmack G, Phillips JW, Roberts CJ, Shoemaker DD. Lum PY, et al. Among authors: stepaniants sb. Cell. 2004 Jan 9;116(1):121-37. doi: 10.1016/s0092-8674(03)01035-3. Cell. 2004. PMID: 14718172 Free article.
Functional discovery via a compendium of expression profiles.
Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH. Hughes TR, et al. Among authors: stepaniants sb. Cell. 2000 Jul 7;102(1):109-26. doi: 10.1016/s0092-8674(00)00015-5. Cell. 2000. PMID: 10929718 Free article.
Rosetta error model for gene expression analysis.
Weng L, Dai H, Zhan Y, He Y, Stepaniants SB, Bassett DE. Weng L, et al. Among authors: stepaniants sb. Bioinformatics. 2006 May 1;22(9):1111-21. doi: 10.1093/bioinformatics/btl045. Epub 2006 Mar 7. Bioinformatics. 2006. PMID: 16522673
Genes related to emphysema are enriched for ubiquitination pathways.
Stepaniants S, Wang IM, Boie Y, Mortimer J, Kennedy B, Elliott M, Hayashi S, Luo H, Wong J, Loy L, Coulter S, Roberts CJ, Hogg JC, Sin DD, O'Neill G, Crackower M, Morris M, Paré PD, Obeidat M. Stepaniants S, et al. BMC Pulm Med. 2014 Nov 29;14:187. doi: 10.1186/1471-2466-14-187. BMC Pulm Med. 2014. PMID: 25432663 Free PMC article.
14 results