Zerwes HG - Search Results

1

Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries.

Wang Y, Burns WR, Tang PC, Yi T, Schechner JS, Zerwes HG, Sessa WC, Lorber MI, Pober JS, Tellides G. Wang Y, et al. Among authors: zerwes hg. FASEB J. 2004 Mar;18(3):606-8. doi: 10.1096/fj.03-0840fje. Epub 2004 Jan 20. FASEB J. 2004. PMID: 14734640

2

Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.

Fiorina P, Jurewicz M, Vergani A, Petrelli A, Carvello M, D'Addio F, Godwin JG, Law K, Wu E, Tian Z, Thoma G, Kovarik J, La Rosa S, Capella C, Rodig S, Zerwes HG, Sayegh MH, Abdi R. Fiorina P, et al. Among authors: zerwes hg. J Immunol. 2011 Jan 1;186(1):121-31. doi: 10.4049/jimmunol.1000799. Epub 2010 Dec 3. J Immunol. 2011. PMID: 21131428 Free PMC article.

3

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.

Thoma G, Baenteli R, Lewis I, Jones D, Kovarik J, Streiff MB, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4745-9. doi: 10.1016/j.bmcl.2011.06.070. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21764306

4

Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.

Thoma G, Beerli C, Bigaud M, Bruns C, Cooke NG, Streiff MB, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2000-5. doi: 10.1016/j.bmcl.2008.01.108. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18267361

5

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Thoma G, Baenteli R, Lewis I, Wagner T, Oberer L, Blum W, Glickman F, Streiff MB, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6185-8. doi: 10.1016/j.bmcl.2009.09.002. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19783143

6

Orally bioavailable competitive CCR5 antagonists.

Thoma G, Nuninger F, Schaefer M, Akyel KG, Albert R, Beerli C, Bruns C, Francotte E, Luyten M, MacKenzie D, Oberer L, Streiff MB, Wagner T, Walter H, Weckbecker G, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2004 Apr 8;47(8):1939-55. doi: 10.1021/jm031046g. J Med Chem. 2004. PMID: 15055994

7

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Martin K, Touil R, Cvijetic G, Israel L, Kolb Y, Sarret S, Valeaux S, Degl'Innocenti E, Le Meur T, Caesar N, Bardet M, Beerli C, Zerwes HG, Kovarik J, Beltz K, Schlapbach A, Quancard J, Régnier CH, Bigaud M, Junt T, Wieczorek G, Isnardi I, Littlewood-Evans A, Bornancin F, Calzascia T. Martin K, et al. Among authors: zerwes hg. Arthritis Rheumatol. 2020 Jun;72(6):919-930. doi: 10.1002/art.41204. Epub 2020 Apr 26. Arthritis Rheumatol. 2020. PMID: 31943941

8

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Hacini-Rachinel F, Hauchard A, Bruno S, Paulat G, Cojean C, Loesle P, Schneider MA, Bourne M, Elain G, Roth L, Urban B, Viebrock S, Leon AO, Röhn TA, Loesche C, Werfel T, Thoma G, Zerwes HG. Hacini-Rachinel F, et al. Among authors: zerwes hg. Exp Dermatol. 2024 May;33(5):e15099. doi: 10.1111/exd.15099. Exp Dermatol. 2024. PMID: 38794814

9

Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

Thoma G, Decoret O, Vangrevelinghe E, Trunzer M, Decker A, Orjuela Leon A, Beerli C, Bruno S, Hauchard A, Paulat G, Zerwes HG, Hacini-Rachinel F. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2023 Nov 9;66(21):15042-15053. doi: 10.1021/acs.jmedchem.3c01735. Epub 2023 Oct 31. J Med Chem. 2023. PMID: 37906573

10

Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.

Thoma G, Vangrevelinghe E, Luneau A, Piechon P, Beerli C, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. ACS Med Chem Lett. 2023 May 30;14(6):841-845. doi: 10.1021/acsmedchemlett.3c00169. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312861 Free PMC article.

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