Wang L - Search Results

1

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. Among authors: wang x, wang gt. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

2

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.

von Geldern TW, Tasker AS, Sorensen BK, Winn M, Szczepankiewicz BG, Dixon DB, Chiou WJ, Wang L, Wessale JL, Adler A, Marsh KC, Nguyen B, Opgenorth TJ. von Geldern TW, et al. Among authors: wang l. J Med Chem. 1999 Sep 9;42(18):3668-78. doi: 10.1021/jm990170q. J Med Chem. 1999. PMID: 10479298

3

Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.

Wang L, Woods KW, Li Q, Barr KJ, McCroskey RW, Hannick SM, Gherke L, Credo RB, Hui YH, Marsh K, Warner R, Lee JY, Zielinski-Mozng N, Frost D, Rosenberg SH, Sham HL. Wang L, et al. J Med Chem. 2002 Apr 11;45(8):1697-711. doi: 10.1021/jm010523x. J Med Chem. 2002. PMID: 11931625

4

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Cohen J, Gu WZ, Frost D, Zhang H, Rosenberg S, Sham H. Lin NH, et al. Among authors: wang l. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1293-6. doi: 10.1016/s0960-894x(03)00122-7. Bioorg Med Chem Lett. 2003. PMID: 12657267

5

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL. Tong Y, et al. Among authors: wang w, wang l. Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. doi: 10.1016/s0960-894x(03)00195-1. Bioorg Med Chem Lett. 2003. PMID: 12699757

6

Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Cohen J, Gu WZ, Frost D, Zhang H, Rosenberg S, Sham H. Lin NH, et al. Among authors: wang l. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3821-5. doi: 10.1016/j.bmcl.2003.07.006. Bioorg Med Chem Lett. 2003. PMID: 14552788

7

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Hasvold LA, Wang W, Gwaltney SL 2nd, Rockway TW, Nelson LT, Mantei RA, Fakhoury SA, Sullivan GM, Li Q, Lin NH, Wang L, Zhang H, Cohen J, Gu WZ, Marsh K, Bauch J, Rosenberg S, Sham HL. Hasvold LA, et al. Among authors: wang w, wang l. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4001-5. doi: 10.1016/j.bmcl.2003.08.058. Bioorg Med Chem Lett. 2003. PMID: 14592494

8

Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.

Wang L, Lin NH, Li Q, Henry RF, Zhang H, Cohen J, Gu WZ, Marsh KC, Bauch JL, Rosenberg SH, Sham HL. Wang L, et al. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4603-6. doi: 10.1016/j.bmcl.2004.07.004. Bioorg Med Chem Lett. 2004. PMID: 15324873

9

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Wang X, Wang GT, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Lin NH, et al. Among authors: wang x, wang gt, wang l. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5057-62. doi: 10.1016/j.bmcl.2004.07.083. Bioorg Med Chem Lett. 2004. PMID: 15380198

10

A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.

Gu WZ, Joseph I, Wang YC, Frost D, Sullivan GM, Wang L, Lin NH, Cohen J, Stoll VS, Jakob CG, Muchmore SW, Harlan JE, Holzman T, Walten KA, Ladror US, Anderson MG, Kroeger P, Rodriguez LE, Jarvis KP, Ferguson D, Marsh K, Ng S, Rosenberg SH, Sham HL, Zhang H. Gu WZ, et al. Among authors: wang l, wang yc. Anticancer Drugs. 2005 Nov;16(10):1059-69. doi: 10.1097/00001813-200511000-00004. Anticancer Drugs. 2005. PMID: 16222147

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