Greenwood JR - Search Results

1

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: greenwood jr. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

2

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

Beich-Frandsen M, Pickering DS, Mirza O, Johansen TN, Greenwood J, Vestergaard B, Schousboe A, Gajhede M, Liljefors T, Kastrup JS. Beich-Frandsen M, et al. J Med Chem. 2008 Mar 13;51(5):1459-63. doi: 10.1021/jm701126w. Epub 2008 Feb 13. J Med Chem. 2008. PMID: 18269227

3

Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Clausen RP, Bräuner-Osborne H, Greenwood JR, Hermit MB, Stensbøl TB, Nielsen B, Krogsgaard-Larsen P. Clausen RP, et al. Among authors: greenwood jr. J Med Chem. 2002 Sep 12;45(19):4240-5. doi: 10.1021/jm020122x. J Med Chem. 2002. PMID: 12213064

4

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

Johansen TN, Greenwood JR, Frydenvang K, Madsen U, Krogsgaard-Larsen P. Johansen TN, et al. Among authors: greenwood jr. Chirality. 2003 Feb;15(2):167-79. doi: 10.1002/chir.10177. Chirality. 2003. PMID: 12520509 Review.

5

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

Bunch L, Liljefors T, Greenwood JR, Frydenvang K, Bräuner-Osborne H, Krogsgaard-Larsen P, Madsen U. Bunch L, et al. Among authors: greenwood jr. J Org Chem. 2003 Feb 21;68(4):1489-95. doi: 10.1021/jo026509p. J Org Chem. 2003. PMID: 12585893

6

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P. Brehm L, et al. Among authors: greenwood jr. J Med Chem. 2003 Apr 10;46(8):1350-8. doi: 10.1021/jm0204441. J Med Chem. 2003. PMID: 12672235

7

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U. Bjerrum EJ, et al. Among authors: greenwood jr. J Med Chem. 2003 May 22;46(11):2246-9. doi: 10.1021/jm020588f. J Med Chem. 2003. PMID: 12747796

8

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

Brehm L, Greenwood JR, Sløk FA, Holm MM, Nielsen B, Geneser U, Stensbøl TB, Bräuner-Osborne H, Begtrup M, Egebjerg J, Krogsgaard-Larsen P. Brehm L, et al. Among authors: greenwood jr. Chirality. 2004 Aug;16(7):452-66. doi: 10.1002/chir.20060. Chirality. 2004. PMID: 15236343

9

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

Clausen RP, Hansen KB, Calí P, Nielsen B, Greenwood JR, Begtrup M, Egebjerg J, Bräuner-Osborne H. Clausen RP, et al. Among authors: greenwood jr. Eur J Pharmacol. 2004 Sep 19;499(1-2):35-44. doi: 10.1016/j.ejphar.2004.07.049. Eur J Pharmacol. 2004. PMID: 15363949

10

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: greenwood jr. J Med Chem. 2005 May 5;48(9):3438-42. doi: 10.1021/jm050014l. J Med Chem. 2005. PMID: 15857151

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