Graham SL - Search Results

1

Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Dinsmore CJ, Zartman CB, Bergman JM, Abrams MT, Buser CA, Culberson JC, Davide JP, Ellis-Hutchings M, Fernandes C, Graham SL, Hartman GD, Huber HE, Lobell RB, Mosser SD, Robinson RG, Williams TM. Dinsmore CJ, et al. Among authors: graham sl. Bioorg Med Chem Lett. 2004 Feb 9;14(3):639-43. doi: 10.1016/j.bmcl.2003.11.051. Bioorg Med Chem Lett. 2004. PMID: 14741259

2

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.

Young SD, Payne LS, Thompson WJ, Gaffin N, Lyle TA, Britcher SF, Graham SL, Schultz TH, Deana AA, Darke PL, et al. Young SD, et al. Among authors: graham sl. J Med Chem. 1992 May 15;35(10):1702-9. doi: 10.1021/jm00088a004. J Med Chem. 1992. PMID: 1588552

3

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: graham sl. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

4

Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides.

Graham SL, Hoffman JM, Gautheron P, Michelson SR, Scholz TH, Schwam H, Shepard KL, Smith AM, Smith RL, Sondey JM, et al. Graham SL, et al. J Med Chem. 1990 Feb;33(2):749-54. doi: 10.1021/jm00164a045. J Med Chem. 1990. PMID: 2299640

5

Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.

Graham SL, Shepard KL, Anderson PS, Baldwin JJ, Best DB, Christy ME, Freedman MB, Gautheron P, Habecker CN, Hoffman JM, et al. Graham SL, et al. J Med Chem. 1989 Dec;32(12):2548-54. doi: 10.1021/jm00132a009. J Med Chem. 1989. PMID: 2585443

6

Pseudodipeptide inhibitors of protein farnesyltransferase.

deSolms SJ, Deana AA, Giuliani EA, Graham SL, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Scholz TH, et al. deSolms SJ, et al. Among authors: graham sl. J Med Chem. 1995 Sep 29;38(20):3967-71. doi: 10.1021/jm00020a010. J Med Chem. 1995. PMID: 7562930

7

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.

Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JP, deSolms SJ, Giuliani EA, Gomez RP, Graham SL, Hamilton K, et al. Kohl NE, et al. Among authors: graham sl. Nat Med. 1995 Aug;1(8):792-7. doi: 10.1038/nm0895-792. Nat Med. 1995. PMID: 7585182

8

Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages.

Wai JS, Bamberger DL, Fisher TE, Graham SL, Smith RL, Gibbs JB, Mosser SD, Oliff AI, Pompliano DL, Rands E, et al. Wai JS, et al. Among authors: graham sl. Bioorg Med Chem. 1994 Sep;2(9):939-47. doi: 10.1016/s0968-0896(00)82043-x. Bioorg Med Chem. 1994. PMID: 7712129

9

Pseudopeptide inhibitors of Ras farnesyl-protein transferase.

Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Breslin MJ, Deana AA, et al. Graham SL, et al. J Med Chem. 1994 Mar 18;37(6):725-32. doi: 10.1021/jm00032a004. J Med Chem. 1994. PMID: 8145221

10

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE. Prendergast GC, et al. Among authors: graham sl. Mol Cell Biol. 1994 Jun;14(6):4193-202. doi: 10.1128/mcb.14.6.4193-4202.1994. Mol Cell Biol. 1994. PMID: 8196657 Free PMC article.

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