Hagen TJ - Search Results

1

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.

Hallinan EA, Hagen TJ, Bergmanis A, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. Among authors: hagen tj. J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f. J Med Chem. 2004. PMID: 14761191

2

N-substituted dibenzoxazepines as analgesic PGE2 antagonists.

Hallinan EA, Hagen TJ, Husa RK, Tsymbalov S, Rao SN, vanHoeck JP, Rafferty MF, Stapelfeld A, Savage MA, Reichman M. Hallinan EA, et al. Among authors: hagen tj. J Med Chem. 1993 Oct 29;36(22):3293-9. doi: 10.1021/jm00074a010. J Med Chem. 1993. PMID: 7901416

3

Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs.

Hallinan EA, Hagen TJ, Tsymbalov S, Husa RK, Lee AC, Stapelfeld A, Savage MA. Hallinan EA, et al. Among authors: hagen tj. J Med Chem. 1996 Jan 19;39(2):609-13. doi: 10.1021/jm950454k. J Med Chem. 1996. PMID: 8558534

4

Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Webber RK, Metz S, Moore WM, Connor JR, Currie MG, Fok KF, Hagen TJ, Hansen DW Jr, Jerome GM, Manning PT, Pitzele BS, Toth MV, Trivedi M, Zupec ME, Tjoeng FS. Webber RK, et al. Among authors: hagen tj. J Med Chem. 1998 Jan 1;41(1):96-101. doi: 10.1021/jm9705059. J Med Chem. 1998. PMID: 9438025

5

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA. Hagen TJ, et al. J Med Chem. 1998 Sep 10;41(19):3675-83. doi: 10.1021/jm970840x. J Med Chem. 1998. PMID: 9733492

6

Specific inhibitors of inducible nitric oxide synthase: efficacy in a rodent model of sepsis.

Fretland DJ, Widomski DL, Anglin CP, Moore W, Jerome G, Kornmeier C, Connor J, Branson L, Wyatt P, Manning P, Toth M, Webber RK, Hansen D, Hallinan EA, Hagen T, Bergmanis A, Pitzele B, Currie MG. Fretland DJ, et al. Inflamm Res. 1999 Dec;48 Suppl 2:S107-8. doi: 10.1007/s000110050540. Inflamm Res. 1999. PMID: 10667837 No abstract available.

7

2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.

Hallinan EA, Hagen TJ, Tsymbalov S, Stapelfeld A, Savage MA. Hallinan EA, et al. Among authors: hagen tj. Bioorg Med Chem. 2001 Jan;9(1):1-6. doi: 10.1016/s0968-0896(00)00229-7. Bioorg Med Chem. 2001. PMID: 11197330

8

3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.

Tsymbalov S, Hagen TJ, Moore WM, Jerome GM, Connor JR, Manning PT, Pitzele BS, Hallinan EA. Tsymbalov S, et al. Among authors: hagen tj. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3337-9. doi: 10.1016/s0960-894x(02)00686-8. Bioorg Med Chem Lett. 2002. PMID: 12392746

9

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.

Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Zhang Z, et al. Among authors: hagen tj. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6860-3. doi: 10.1016/j.bmcl.2013.09.101. Epub 2013 Oct 8. Bioorg Med Chem Lett. 2013. PMID: 24157367 Free PMC article.

10

Discovery of triazines as selective PDE4B versus PDE4D inhibitors.

Hagen TJ, Mo X, Burgin AB, Fox D 3rd, Zhang Z, Gurney ME. Hagen TJ, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):4031-4. doi: 10.1016/j.bmcl.2014.06.002. Epub 2014 Jun 12. Bioorg Med Chem Lett. 2014. PMID: 24998378 Free PMC article.

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