Bohl C - Search Results

1

Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators.

Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, Bohl C, Dalton JT, Miller DD. Marhefka CA, et al. Among authors: bohl c. J Med Chem. 2004 Feb 12;47(4):993-8. doi: 10.1021/jm030336u. J Med Chem. 2004. PMID: 14761201 Free PMC article.

2

A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.

Bohl CE, Chang C, Mohler ML, Chen J, Miller DD, Swaan PW, Dalton JT. Bohl CE, et al. J Med Chem. 2004 Jul 15;47(15):3765-76. doi: 10.1021/jm0499007. J Med Chem. 2004. PMID: 15239655 Free PMC article.

3

Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.

Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT. Bohl CE, et al. J Biol Chem. 2005 Nov 11;280(45):37747-54. doi: 10.1074/jbc.M507464200. Epub 2005 Aug 29. J Biol Chem. 2005. PMID: 16129672 Free PMC article.

4

In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring.

Chen J, Hwang DJ, Chung K, Bohl CE, Fisher SJ, Miller DD, Dalton JT. Chen J, et al. Endocrinology. 2005 Dec;146(12):5444-54. doi: 10.1210/en.2005-0732. Epub 2005 Sep 15. Endocrinology. 2005. PMID: 16166218 Free PMC article.

5

Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.

Bohl CE, Wu Z, Miller DD, Bell CE, Dalton JT. Bohl CE, et al. J Biol Chem. 2007 May 4;282(18):13648-55. doi: 10.1074/jbc.M611711200. Epub 2007 Feb 20. J Biol Chem. 2007. PMID: 17311914 Free PMC article.

6

Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.

Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Bohl CE, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. doi: 10.1016/j.bmcl.2008.09.002. Epub 2008 Sep 5. Bioorg Med Chem Lett. 2008. PMID: 18805694 Free PMC article.

7

Selective androgen receptor modulators in preclinical and clinical development.

Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Narayanan R, et al. Nucl Recept Signal. 2008;6:e010. doi: 10.1621/nrs.06010. Epub 2008 Nov 26. Nucl Recept Signal. 2008. PMID: 19079612 Free PMC article. Review.

8

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

Mohler ML, Bohl CE, Jones A, Coss CC, Narayanan R, He Y, Hwang DJ, Dalton JT, Miller DD. Mohler ML, et al. Among authors: bohl ce. J Med Chem. 2009 Jun 25;52(12):3597-617. doi: 10.1021/jm900280m. J Med Chem. 2009. PMID: 19432422 Review. No abstract available.

9

Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets.

Duke CB, Jones A, Bohl CE, Dalton JT, Miller DD. Duke CB, et al. J Med Chem. 2011 Jun 9;54(11):3973-6. doi: 10.1021/jm2000097. Epub 2011 May 16. J Med Chem. 2011. PMID: 21506597

10

A selective androgen receptor modulator for hormonal male contraception.

Chen J, Hwang DJ, Bohl CE, Miller DD, Dalton JT. Chen J, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):546-53. doi: 10.1124/jpet.104.075424. Epub 2004 Sep 3. J Pharmacol Exp Ther. 2005. PMID: 15347734

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