Dersch CM - Search Results

1

Importance of phenolic address groups in opioid kappa receptor selective antagonists.

Thomas JB, Fix SE, Rothman RB, Mascarella SW, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 2004 Feb 12;47(4):1070-3. doi: 10.1021/jm030467v. J Med Chem. 2004. PMID: 14761209

2

Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.

Thomas JB, Atkinson RN, Namdev N, Rothman RB, Gigstad KM, Fix SE, Mascarella SW, Burgess JP, Vinson NA, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 2002 Aug 1;45(16):3524-30. doi: 10.1021/jm020084h. J Med Chem. 2002. PMID: 12139463

3

Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.

Schütz J, Dersch CM, Horel R, Spetea M, Koch M, Meditz R, Greiner E, Rothman RB, Schmidhammer H. Schütz J, et al. Among authors: dersch cm. J Med Chem. 2002 Nov 21;45(24):5378-83. doi: 10.1021/jm020940p. J Med Chem. 2002. PMID: 12431065

4

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 2003 Jul 3;46(14):3127-37. doi: 10.1021/jm030094y. J Med Chem. 2003. PMID: 12825951

5

A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.

Kim IJ, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Kim IJ, et al. Among authors: dersch cm. Bioorg Med Chem. 2004 Aug 15;12(16):4543-50. doi: 10.1016/j.bmc.2004.05.038. Bioorg Med Chem. 2004. PMID: 15265502

6

Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.

Thomas JB, Mascarella SW, Rothman RB, Partilla JS, Xu H, McCullough KB, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 1998 May 21;41(11):1980-90. doi: 10.1021/jm980063g. J Med Chem. 1998. PMID: 9599247

7

N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

Thomas JB, Zheng X, Mascarella SW, Rothman RB, Dersch CM, Partilla JS, Flippen-Anderson JL, George CF, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 1998 Oct 8;41(21):4143-9. doi: 10.1021/jm980290i. J Med Chem. 1998. PMID: 9767649

8

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Thomas JB, Fall MJ, Cooper JB, Rothman RB, Mascarella SW, Xu H, Partilla JS, Dersch CM, McCullough KB, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. J Med Chem. 1998 Dec 17;41(26):5188-97. doi: 10.1021/jm980511k. J Med Chem. 1998. PMID: 9857089

9

(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.

Thomas JB, Herault XM, Rothman RB, Burgess JP, Mascarella SW, Xu H, Horel RB, Dersch CM, Carroll FI. Thomas JB, et al. Among authors: dersch cm. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3053-6. doi: 10.1016/s0960-894x(99)00525-9. Bioorg Med Chem Lett. 1999. PMID: 10571174

10

Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.

Thomas JB, Atkinson RN, Herault XM, Rothman RB, Mascarella SW, Dersch CM, Xu H, Horel RB, Carroll FI. Thomas JB, et al. Among authors: dersch cm. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3347-50. doi: 10.1016/s0960-894x(99)00613-7. Bioorg Med Chem Lett. 1999. PMID: 10612597

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