Ashton WT - Search Results

1

Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.

Ashton WT, Cantone CL, Tolman RL, Greenlee WJ, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. J Med Chem. 1992 Jul 24;35(15):2772-81. doi: 10.1021/jm00093a009. J Med Chem. 1992. PMID: 1495010

2

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

3

Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.

Ashton WT, Meurer LC, Cantone CL, Field AK, Hannah J, Karkas JD, Liou R, Patel GF, Perry HC, Wagner AF, et al. Ashton WT, et al. J Med Chem. 1988 Dec;31(12):2304-15. doi: 10.1021/jm00120a010. J Med Chem. 1988. PMID: 2848125

4

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Kivlighn SD, Siegl PK, Lotti VJ, Chang RS, et al. Chang LL, et al. Among authors: ashton wt. J Med Chem. 1995 Sep 15;38(19):3741-58. doi: 10.1021/jm00019a004. J Med Chem. 1995. PMID: 7562905

5

Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes.

Chang LL, Ashton WT, Flanagan KL, Chen TB, O'Malley SS, Zingaro GJ, Siegl PK, Kivlighn SD, Lotti VJ, Chang RS, et al. Chang LL, et al. Among authors: ashton wt. J Med Chem. 1994 Dec 23;37(26):4464-78. doi: 10.1021/jm00052a006. J Med Chem. 1994. PMID: 7799397

6

Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.

Ashton WT, Chang LL, Flanagan KL, Hutchins SM, Naylor EM, Chakravarty PK, Patchett AA, Greenlee WJ, Chen TB, Faust KA, et al. Ashton WT, et al. J Med Chem. 1994 Aug 19;37(17):2808-24. doi: 10.1021/jm00043a020. J Med Chem. 1994. PMID: 8064808

7

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates.

Ashton WT, Hutchins SM, Greenlee WJ, Doss GA, Chang RS, Lotti VJ, Faust KA, Chen TB, Zingaro GJ, Kivlighn SD, et al. Ashton WT, et al. J Med Chem. 1993 Nov 12;36(23):3595-605. doi: 10.1021/jm00075a014. J Med Chem. 1993. PMID: 8246227

8

Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones.

Chang LL, Ashton WT, Flanagan KL, Strelitz RA, MacCoss M, Greenlee WJ, Chang RS, Lotti VJ, Faust KA, Chen TB, et al. Chang LL, et al. Among authors: ashton wt. J Med Chem. 1993 Aug 20;36(17):2558-68. doi: 10.1021/jm00069a015. J Med Chem. 1993. PMID: 8355255

9

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.

Ashton WT, Cantone CL, Chang LL, Hutchins SM, Strelitz RA, MacCoss M, Chang RS, Lotti VJ, Faust KA, Chen TB, et al. Ashton WT, et al. J Med Chem. 1993 Mar 5;36(5):591-609. doi: 10.1021/jm00057a009. J Med Chem. 1993. PMID: 8496939

10

In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.

Gabel RA, Kivlighn SD, Zingaro GJ, Schorn TW, Schaffer LW, Ashton WT, Chang LL, Flanagan K, Greenlee WJ, Siegl PK. Gabel RA, et al. Among authors: ashton wt. Clin Exp Hypertens. 1995 Aug;17(6):931-53. doi: 10.3109/10641969509033644. Clin Exp Hypertens. 1995. PMID: 7581262

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