Leask A - Search Results

1

Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.

Leask A, Denton CP, Abraham DJ. Leask A, et al. J Invest Dermatol. 2004 Jan;122(1):1-6. doi: 10.1046/j.0022-202X.2003.22133.x. J Invest Dermatol. 2004. PMID: 14962082 Free article. Review.

2

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.

Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y, Leask A. Abraham DJ, et al. Among authors: leask a. J Biol Chem. 2000 May 19;275(20):15220-5. doi: 10.1074/jbc.275.20.15220. J Biol Chem. 2000. PMID: 10809757 Free article.

3

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM, Martin GR, Black CM, Abraham DJ. Shi-wen X, et al. Among authors: leask a. Exp Cell Res. 2000 Aug 25;259(1):213-24. doi: 10.1006/excr.2000.4972. Exp Cell Res. 2000. PMID: 10942593

4

CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.

Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A. Holmes A, et al. Among authors: leask a. J Biol Chem. 2001 Apr 6;276(14):10594-601. doi: 10.1074/jbc.M010149200. Epub 2001 Jan 4. J Biol Chem. 2001. PMID: 11152469 Free article.

5

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.

Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ. Leask A, et al. Mol Pathol. 2001 Jun;54(3):180-3. doi: 10.1136/mp.54.3.180. Mol Pathol. 2001. PMID: 11376132 Free PMC article.

6

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.

Stratton R, Shiwen X, Martini G, Holmes A, Leask A, Haberberger T, Martin GR, Black CM, Abraham D. Stratton R, et al. Among authors: leask a. J Clin Invest. 2001 Jul;108(2):241-50. doi: 10.1172/JCI12020. J Clin Invest. 2001. PMID: 11457877 Free PMC article. Clinical Trial.

7

Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.

Leask A, Holmes A, Abraham DJ. Leask A, et al. Curr Rheumatol Rep. 2002 Apr;4(2):136-42. doi: 10.1007/s11926-002-0009-x. Curr Rheumatol Rep. 2002. PMID: 11890879 Review.

8

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR, Connolly MK. Leask A, et al. Arthritis Rheum. 2002 Jul;46(7):1857-65. doi: 10.1002/art.10333. Arthritis Rheum. 2002. PMID: 12124870 Free article.

9

CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A. Chen Y, et al. Among authors: leask a. Kidney Int. 2002 Oct;62(4):1149-59. doi: 10.1111/j.1523-1755.2002.kid567.x. Kidney Int. 2002. PMID: 12234285 Free article.

10

Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.

Stratton R, Rajkumar V, Ponticos M, Nichols B, Shiwen X, Black CM, Abraham DJ, Leask A. Stratton R, et al. Among authors: leask a. FASEB J. 2002 Dec;16(14):1949-51. doi: 10.1096/fj.02-0204fje. Epub 2002 Oct 4. FASEB J. 2002. PMID: 12368229

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