van Aalten DM - Search Results

1

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.

Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM. Komander D, et al. Among authors: van aalten dm. Structure. 2004 Feb;12(2):215-26. doi: 10.1016/j.str.2004.01.005. Structure. 2004. PMID: 14962382 Free article.

2

Structural insights into the catalytic mechanism of a family 18 exo-chitinase.

van Aalten DM, Komander D, Synstad B, Gåseidnes S, Peter MG, Eijsink VG. van Aalten DM, et al. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8979-84. doi: 10.1073/pnas.151103798. Proc Natl Acad Sci U S A. 2001. PMID: 11481469 Free PMC article.

3

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Biochem J. 2001 Sep 1;358(Pt 2):287-94. doi: 10.1042/0264-6021:3580287. Biochem J. 2001. PMID: 11513726 Free PMC article.

4

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.

Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM. Tabudravu JN, et al. Among authors: van aalten dm. Bioorg Med Chem. 2002 Apr;10(4):1123-8. doi: 10.1016/s0968-0896(01)00372-8. Bioorg Med Chem. 2002. PMID: 11836123

5

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM. Biondi RM, et al. Among authors: van aalten dm. EMBO J. 2002 Aug 15;21(16):4219-28. doi: 10.1093/emboj/cdf437. EMBO J. 2002. PMID: 12169624 Free PMC article.

6

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.

Thomas CC, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Curr Biol. 2002 Jul 23;12(14):1256-62. doi: 10.1016/s0960-9822(02)00972-7. Curr Biol. 2002. PMID: 12176338 Free article.

7

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Among authors: van aalten dm. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

8

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Biochem J. 2003 Nov 1;375(Pt 3):531-8. doi: 10.1042/BJ20031229. Biochem J. 2003. PMID: 12964941 Free PMC article.

9

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.

Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Nat Struct Mol Biol. 2004 Feb;11(2):193-200. doi: 10.1038/nsmb716. Epub 2004 Jan 18. Nat Struct Mol Biol. 2004. PMID: 14730349

10

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

Komander D, Deak M, Morrice N, van Aalten DM. Komander D, et al. Among authors: van aalten dm. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):314-6. doi: 10.1107/S0907444903028518. Epub 2004 Jan 23. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14747709

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