Steenwyk RC - Search Results

1

Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl]piperazine: kinetic characterization and evidence for apoprotein adduction.

Hutzler JM, Steenwyk RC, Smith EB, Walker GS, Wienkers LC. Hutzler JM, et al. Among authors: steenwyk rc. Chem Res Toxicol. 2004 Feb;17(2):174-84. doi: 10.1021/tx034199f. Chem Res Toxicol. 2004. PMID: 14967005

2

Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes.

Steenwyk RC, Hutzler JM, Sams J, Shen Z, Siuzdak G. Steenwyk RC, et al. Rapid Commun Mass Spectrom. 2006;20(24):3717-22. doi: 10.1002/rcm.2796. Rapid Commun Mass Spectrom. 2006. PMID: 17117443

3

Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2.

Wienkers LC, Steenwyk RC, Hauer MJ, Fleishaker JC, Pearson PG. Wienkers LC, et al. Among authors: steenwyk rc. J Pharmacol Exp Ther. 1998 Nov;287(2):583-90. J Pharmacol Exp Ther. 1998. PMID: 9808684

4

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.

Wienkers LC, Steenwyk RC, Sanders PE, Pearson PG. Wienkers LC, et al. Among authors: steenwyk rc. J Pharmacol Exp Ther. 1996 May;277(2):982-90. J Pharmacol Exp Ther. 1996. PMID: 8627581

5

In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase.

Wienkers LC, Steenwyk RC, Mizsak SA, Pearson PG. Wienkers LC, et al. Among authors: steenwyk rc. Drug Metab Dispos. 1995 Mar;23(3):383-92. Drug Metab Dispos. 1995. PMID: 7628305

6

Identification of N-acetylcysteine conjugates of 1,2-dibromo-3-chloropropane: evidence for cytochrome P450 and glutathione mediated bioactivation pathways.

Weber GL, Steenwyk RC, Nelson SD, Pearson PG. Weber GL, et al. Among authors: steenwyk rc. Chem Res Toxicol. 1995 Jun;8(4):560-73. doi: 10.1021/tx00046a010. Chem Res Toxicol. 1995. PMID: 7548736

7

Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: II. Multiple-dose administration.

Fleishaker JC, Peters GR, Cathcart KS, Steenwyk RC. Fleishaker JC, et al. Among authors: steenwyk rc. J Clin Pharmacol. 1993 Feb;33(2):182-90. doi: 10.1002/j.1552-4604.1993.tb03941.x. J Clin Pharmacol. 1993. PMID: 8440768 Clinical Trial.

8

Inhibition of in vitro lipid peroxidation by 21-aminosteroids. Evidence for differential mechanisms.

Ryan TP, Steenwyk RC, Pearson PG, Petry TW. Ryan TP, et al. Among authors: steenwyk rc. Biochem Pharmacol. 1993 Sep 1;46(5):877-84. doi: 10.1016/0006-2952(93)90497-k. Biochem Pharmacol. 1993. PMID: 8373438

9

Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine.

Lasher TA, Fleishaker JC, Steenwyk RC, Antal EJ. Lasher TA, et al. Among authors: steenwyk rc. Psychopharmacology (Berl). 1991;104(3):323-7. doi: 10.1007/BF02246031. Psychopharmacology (Berl). 1991. PMID: 1924640 Clinical Trial.

10

Replacing 14C with stable isotopes in drug metabolism studies.

Abramson FP, Teffera Y, Kusmierz J, Steenwyk RC, Pearson PG. Abramson FP, et al. Among authors: steenwyk rc. Drug Metab Dispos. 1996 Jul;24(7):697-701. Drug Metab Dispos. 1996. PMID: 8818564

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