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Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ mobilization.
Jin YR, Cho MR, Ryu CK, Chung JH, Yuk DY, Hong JT, Lee KS, Lee JJ, Lee MY, Lim Y, Yun YP. Jin YR, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):214-9. doi: 10.1124/jpet.104.073718. Epub 2004 Aug 24. J Pharmacol Exp Ther. 2005. PMID: 15328379
Antithrombotic and antiplatelet activities of Korean red ginseng extract.
Jin YR, Yu JY, Lee JJ, You SH, Chung JH, Noh JY, Im JH, Han XH, Kim TJ, Shin KS, Wee JJ, Yun YP. Jin YR, et al. Basic Clin Pharmacol Toxicol. 2007 Mar;100(3):170-5. doi: 10.1111/j.1742-7843.2006.00033.x. Basic Clin Pharmacol Toxicol. 2007. PMID: 17309520 Free article.
YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells.
Seo JM, Kim TJ, Jin YR, Han HJ, Ryu CK, Sheen YY, Kim DW, Yun YP. Seo JM, et al. Among authors: jin yr. Eur J Pharmacol. 2008 May 31;586(1-3):74-81. doi: 10.1016/j.ejphar.2008.02.076. Epub 2008 Mar 4. Eur J Pharmacol. 2008. PMID: 18402936
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