Prestwich GD - Search Results

1

Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid.

Xu Y, Fang Y, Chen J, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1461-4. doi: 10.1016/j.bmcl.2004.01.020. Bioorg Med Chem Lett. 2004. PMID: 15006382

2

Synthesis of chiral (alpha,alpha-difluoroalkyl)phosphonate analogues of (lyso)phosphatidic acid via hydrolytic kinetic resolution.

Xu Y, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Org Lett. 2002 Nov 14;4(23):4021-4. doi: 10.1021/ol026684s. Org Lett. 2002. PMID: 12423076

3

Synthesis of monofluorinated analogues of lysophosphatidic acid.

Xu Y, Qian L, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Org Chem. 2003 Jun 27;68(13):5320-30. doi: 10.1021/jo020729l. J Org Chem. 2003. PMID: 12816494

4

Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.

Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD. Qian L, et al. Among authors: prestwich gd. J Med Chem. 2003 Dec 18;46(26):5575-8. doi: 10.1021/jm034207p. J Med Chem. 2003. PMID: 14667211

5

Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.

Xu Y, Tanaka M, Arai H, Aoki J, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5323-8. doi: 10.1016/j.bmcl.2004.08.019. Bioorg Med Chem Lett. 2004. PMID: 15454220

6

Structure-activity relationships of fluorinated lysophosphatidic acid analogues.

Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Med Chem. 2005 May 5;48(9):3319-27. doi: 10.1021/jm049186t. J Med Chem. 2005. PMID: 15857137

7

Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors.

Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Med Chem. 2006 Aug 24;49(17):5309-15. doi: 10.1021/jm060351+. J Med Chem. 2006. PMID: 16913720

8

Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate.

Zhang H, Xu Y, Markadieu N, Beauwens R, Erneux C, Prestwich GD. Zhang H, et al. Among authors: prestwich gd. Bioorg Med Chem Lett. 2008 Jan 15;18(2):762-6. doi: 10.1016/j.bmcl.2007.11.041. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18060773 Free PMC article.

9

New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

Prestwich GD, Xu Y, Qian L, Gajewiak J, Jiang G. Prestwich GD, et al. Biochem Soc Trans. 2005 Dec;33(Pt 6):1357-61. doi: 10.1042/BST0331357. Biochem Soc Trans. 2005. PMID: 16246118 Review.

10

Concise synthesis of acyl migration-blocked 1,1-difluorinated analogues of lysophosphatidic acid.

Xu Y, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Org Chem. 2002 Oct 4;67(20):7158-61. doi: 10.1021/jo0203037. J Org Chem. 2002. PMID: 12354017

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