Randolph JT - Search Results

1

Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A.

Randolph JT, Sauer DR, Haviv F, Nilius AM, Greer J. Randolph JT, et al. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1599-602. doi: 10.1016/j.bmcl.2003.12.059. Bioorg Med Chem Lett. 2004. PMID: 15006412

2

Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.

Randolph JT, Waid P, Nichols C, Sauer D, Haviv F, Diaz G, Bammert G, Besecke LM, Segreti JA, Mohning KM, Bush EN, Wegner CD, Greer J. Randolph JT, et al. J Med Chem. 2004 Feb 26;47(5):1085-97. doi: 10.1021/jm030418i. J Med Chem. 2004. PMID: 14971889

3

Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.

Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ. Huang PP, et al. Among authors: randolph jt. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4075-8. doi: 10.1016/j.bmcl.2004.05.036. Bioorg Med Chem Lett. 2004. PMID: 15225729

4

Oximinoarylsulfonamides as potent HIV protease inhibitors.

Yeung CM, Klein LL, Flentge CA, Randolph JT, Zhao C, Sun M, Dekhtyar T, Stoll VS, Kempf DJ. Yeung CM, et al. Among authors: randolph jt. Bioorg Med Chem Lett. 2005 May 2;15(9):2275-8. doi: 10.1016/j.bmcl.2005.03.008. Bioorg Med Chem Lett. 2005. PMID: 15837308

5

Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.

Randolph JT, Huang PP, Flosi WJ, DeGoey D, Klein LL, Yeung CM, Flentge C, Sun M, Zhao C, Dekhtyar T, Mo H, Colletti L, Kati W, Marsh KC, Molla A, Kempf DJ. Randolph JT, et al. Bioorg Med Chem. 2006 Jun 15;14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504523

6

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.

Randolph JT, Zhang X, Huang PP, Klein LL, Kurtz KA, Konstantinidis AK, He W, Kati WM, Kempf DJ. Randolph JT, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2745-50. doi: 10.1016/j.bmcl.2008.02.053. Epub 2008 Feb 26. Bioorg Med Chem Lett. 2008. PMID: 18375121

7

2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.

Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ. Degoey DA, et al. Among authors: randolph jt. J Med Chem. 2009 Apr 23;52(8):2571-86. doi: 10.1021/jm900044w. J Med Chem. 2009. PMID: 19323562

8

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

Randolph JT, Flentge CA, Huang PP, Hutchinson DK, Klein LL, Lim HB, Mondal R, Reisch T, Montgomery DA, Jiang WW, Masse SV, Hernandez LE, Henry RF, Liu Y, Koev G, Kati WM, Stewart KD, Beno DW, Molla A, Kempf DJ. Randolph JT, et al. J Med Chem. 2009 May 28;52(10):3174-83. doi: 10.1021/jm801485z. J Med Chem. 2009. PMID: 19402666

9

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.

Flentge CA, Randolph JT, Huang PP, Klein LL, Marsh KC, Harlan JE, Kempf DJ. Flentge CA, et al. Among authors: randolph jt. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5444-8. doi: 10.1016/j.bmcl.2009.07.118. Epub 2009 Jul 30. Bioorg Med Chem Lett. 2009. PMID: 19679477

10

Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.

Liu Y, Lim BH, Jiang WW, Flentge CA, Hutchinson DK, Madigan DL, Randolph JT, Wagner R, Maring CJ, Kati WM, Molla A. Liu Y, et al. Among authors: randolph jt. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3747-50. doi: 10.1016/j.bmcl.2012.04.017. Epub 2012 Apr 10. Bioorg Med Chem Lett. 2012. PMID: 22542020

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