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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity.
Shinkawa T, Nakamura K, Yamane N, Shoji-Hosaka E, Kanda Y, Sakurada M, Uchida K, Anazawa H, Satoh M, Yamasaki M, Hanai N, Shitara K. Shinkawa T, et al. J Biol Chem. 2003 Jan 31;278(5):3466-73. doi: 10.1074/jbc.M210665200. Epub 2002 Nov 8. J Biol Chem. 2003. PMID: 12427744 Free article.
Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies.
Mori K, Iida S, Yamane-Ohnuki N, Kanda Y, Kuni-Kamochi R, Nakano R, Imai-Nishiya H, Okazaki A, Shinkawa T, Natsume A, Niwa R, Shitara K, Satoh M. Mori K, et al. Among authors: shinkawa t. Cytotechnology. 2007 Dec;55(2-3):109-14. doi: 10.1007/s10616-007-9103-2. Epub 2007 Oct 31. Cytotechnology. 2007. PMID: 19003000 Free PMC article.
224 results