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452 results

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Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
Balasubramanian BN, St Laurent DR, Saulnier MG, Long BH, Bachand C, Beaulieu F, Clarke W, Deshpande M, Eummer J, Fairchild CR, Frennesson DB, Kramer R, Lee FY, Mahler M, Martel A, Naidu BN, Rose WC, Russell J, Ruediger E, Solomon C, Stoffan KM, Wong H, Wright JJ, Zimmermann K, Vyas DM. Balasubramanian BN, et al. Among authors: mahler m. J Med Chem. 2004 Mar 25;47(7):1609-12. doi: 10.1021/jm034197s. J Med Chem. 2004. PMID: 15027851
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
Saulnier MG, Balasubramanian BN, Long BH, Frennesson DB, Ruediger E, Zimmermann K, Eummer JT, St Laurent DR, Stoffan KM, Naidu BN, Mahler M, Beaulieu F, Bachand C, Lee FY, Fairchild CR, Stadnick LK, Rose WC, Solomon C, Wong H, Martel A, Wright JJ, Kramer R, Langley DR, Vyas DM. Saulnier MG, et al. Among authors: mahler m. J Med Chem. 2005 Apr 7;48(7):2258-61. doi: 10.1021/jm049090z. J Med Chem. 2005. PMID: 15801816
Patterns and predictors of multiple sclerosis phenotype transition.
Pontieri L, Greene N, Wandall-Holm MF, Geertsen SS, Asgari N, Jensen HB, Illes Z, Schäfer J, Jensen RM, Sejbæk T, Weglewski A, Mahler MR, Poulsen MB, Prakash S, Stilund M, Kant M, Rasmussen PV, Svendsen KB, Sellebjerg F, Magyari M. Pontieri L, et al. Among authors: mahler mr. Brain Commun. 2024 Nov 23;6(6):fcae422. doi: 10.1093/braincomms/fcae422. eCollection 2024. Brain Commun. 2024. PMID: 39713244 Free PMC article.
Clinical Predictors of Cisplatin Chemoradiation-Induced Ototoxicity in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study.
Lee JJ, Alamleh S, Zhan LJ, Hueniken K, Mahler MB, Billfalk-Kelly A, Davies J, Brown MC, Spreafico A, Huang SH, Hope A, Xu W, Goldstein DP, Liu G. Lee JJ, et al. Among authors: mahler mb. J Otolaryngol Head Neck Surg. 2024 Jan-Dec;53:19160216241248671. doi: 10.1177/19160216241248671. J Otolaryngol Head Neck Surg. 2024. PMID: 39056507 Free PMC article.
Utility of testing for third-generation anticyclic citrullinated peptide (anti-CCP3) antibodies in individuals who present with new musculoskeletal symptoms but have a negative second-generation anticyclic citrullinated peptide (anti-CCP2) antibody test.
Di Matteo A, Mankia K, Garcia-Montoya L, Sharrack S, Duquenne L, Nam JL, Mahler M, Emery P. Di Matteo A, et al. Among authors: mahler m. RMD Open. 2024 Apr 10;10(2):e003927. doi: 10.1136/rmdopen-2023-003927. RMD Open. 2024. PMID: 38599655 Free PMC article.
452 results