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Page 1
Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.
Sone H, Shimano H, Shu M, Nakakuki M, Takahashi A, Sakai M, Sakamoto Y, Yokoo T, Matsuzaka K, Okazaki H, Nakagawa Y, Iida KT, Suzuki H, Toyoshima H, Horiuchi S, Yamada N. Sone H, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2004 Apr 9;316(3):790-4. doi: 10.1016/j.bbrc.2004.02.121. Biochem Biophys Res Commun. 2004. PMID: 15033469
Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.
Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H. Osaki Y, et al. Among authors: takahashi a. Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14. Biochem Biophys Res Commun. 2015. PMID: 26381177
Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.
Sone H, Shimano H, Sakakura Y, Inoue N, Amemiya-Kudo M, Yahagi N, Osawa M, Suzuki H, Yokoo T, Takahashi A, Iida K, Toyoshima H, Iwama A, Yamada N. Sone H, et al. Among authors: takahashi a. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E222-30. doi: 10.1152/ajpendo.00189.2001. Am J Physiol Endocrinol Metab. 2002. PMID: 11739104 Free article.
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N. Ide T, et al. Among authors: takahashi a. Mol Endocrinol. 2003 Jul;17(7):1255-67. doi: 10.1210/me.2002-0191. Epub 2003 May 1. Mol Endocrinol. 2003. PMID: 12730332
In luciferase reporter gene assays, overexpression of LXRalpha or beta suppressed PPARalpha-induced peroxisome proliferator response element-luciferase activity in a dose-dependent manner. LXR agonists, T0901317 and 22(R)-hydroxycholesterol, dose dependently enhanced the s …
In luciferase reporter gene assays, overexpression of LXRalpha or beta suppressed PPARalpha-induced peroxisome proliferator response element …
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N. Yamamoto T, et al. Among authors: takahashi a. J Biol Chem. 2004 Mar 26;279(13):12027-35. doi: 10.1074/jbc.M310333200. Epub 2004 Jan 13. J Biol Chem. 2004. PMID: 14722127 Free article.
SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N. Ide T, et al. Among authors: takahashi a. Nat Cell Biol. 2004 Apr;6(4):351-7. doi: 10.1038/ncb1111. Epub 2004 Mar 14. Nat Cell Biol. 2004. PMID: 15048126
4,925 results