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Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G. Andreozzi F, et al. Among authors: laratta e. Endocrinology. 2004 Jun;145(6):2845-57. doi: 10.1210/en.2003-0939. Epub 2004 Mar 4. Endocrinology. 2004. PMID: 15001544
The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P. Sesti G, et al. Among authors: laratta e. J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. doi: 10.1210/jc.2005-2323. Epub 2006 Apr 4. J Clin Endocrinol Metab. 2006. PMID: 16595597
IL-18 gene polymorphism and metabolic syndrome.
Presta I, Andreozzi F, Succurro E, Marini MA, Laratta E, Lauro R, Hribal ML, Perticone F, Sesti G. Presta I, et al. Among authors: laratta e. Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):e5-6. doi: 10.1016/j.numecd.2008.10.002. Epub 2009 Jan 26. Nutr Metab Cardiovasc Dis. 2009. PMID: 19176284 No abstract available.
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