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Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G. D'Alessandris C, et al. Among authors: del guerra s, del prato s. FASEB J. 2004 Jun;18(9):959-61. doi: 10.1096/fj.03-0725fje. Epub 2004 Apr 1. FASEB J. 2004. PMID: 15059979
Lipotoxicity in human pancreatic islets and the protective effect of metformin.
Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P. Lupi R, et al. Among authors: del guerra s, del prato s. Diabetes. 2002 Feb;51 Suppl 1:S134-7. doi: 10.2337/diabetes.51.2007.s134. Diabetes. 2002. PMID: 11815472
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Lupi R, et al. Among authors: del guerra s, del prato s. Diabetes. 2002 May;51(5):1437-42. doi: 10.2337/diabetes.51.5.1437. Diabetes. 2002. PMID: 11978640
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G. Andreozzi F, et al. Among authors: del guerra s, del prato s. Endocrinology. 2004 Jun;145(6):2845-57. doi: 10.1210/en.2003-0939. Epub 2004 Mar 4. Endocrinology. 2004. PMID: 15001544
Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.
Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U, Del Prato S, Dotta F, Marchetti P. Lupi R, et al. Among authors: del guerra s, del chiaro m, del prato s. Diabetes Metab Res Rev. 2004 May-Jun;20(3):246-51. doi: 10.1002/dmrr.460. Diabetes Metab Res Rev. 2004. PMID: 15133757
561 results