Jayaram HN - Search Results

1

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

Pankiewicz KW, Patterson SE, Black PL, Jayaram HN, Risal D, Goldstein BM, Stuyver LJ, Schinazi RF. Pankiewicz KW, et al. Among authors: jayaram hn. Curr Med Chem. 2004 Apr;11(7):887-900. doi: 10.2174/0929867043455648. Curr Med Chem. 2004. PMID: 15083807 Review.

2

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.

Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM. Pankiewicz KW, et al. Among authors: jayaram hn. J Med Chem. 2002 Jan 31;45(3):703-12. doi: 10.1021/jm0104116. J Med Chem. 2002. PMID: 11806722

3

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN. Pankiewicz KW, et al. Among authors: jayaram hn. Curr Med Chem. 2002 Apr;9(7):733-41. doi: 10.2174/0929867024606920. Curr Med Chem. 2002. PMID: 11966436

4

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.

Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. Chen L, et al. Among authors: jayaram hn. J Med Chem. 2007 Nov 15;50(23):5743-51. doi: 10.1021/jm070568j. Epub 2007 Oct 24. J Med Chem. 2007. PMID: 17958343

5

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Chen L, Wilson D, Jayaram HN, Pankiewicz KW. Chen L, et al. Among authors: jayaram hn. J Med Chem. 2007 Dec 27;50(26):6685-91. doi: 10.1021/jm070864w. Epub 2007 Nov 27. J Med Chem. 2007. PMID: 18038969

6

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW. Chen L, et al. Among authors: jayaram hn. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3152-5. doi: 10.1016/j.bmcl.2007.03.035. Epub 2007 Mar 15. Bioorg Med Chem Lett. 2007. PMID: 17395461

7

Mycophenolic acid analogs with a modified metabolic profile.

Chen L, Wilson DJ, Labello NP, Jayaram HN, Pankiewicz KW. Chen L, et al. Among authors: jayaram hn. Bioorg Med Chem. 2008 Oct 15;16(20):9340-5. doi: 10.1016/j.bmc.2008.08.062. Epub 2008 Aug 29. Bioorg Med Chem. 2008. PMID: 18809333

8

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

Felczak K, Chen L, Wilson D, Williams J, Vince R, Petrelli R, Jayaram HN, Kusumanchi P, Kumar M, Pankiewicz KW. Felczak K, et al. Among authors: jayaram hn. Bioorg Med Chem. 2011 Mar 1;19(5):1594-605. doi: 10.1016/j.bmc.2011.01.042. Epub 2011 Jan 27. Bioorg Med Chem. 2011. PMID: 21324702

9

Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.

Pankiewicz KW, Zeidler J, Ciszewski LA, Bell JE, Goldstein BM, Jayaram HN, Watanabe KA. Pankiewicz KW, et al. Among authors: jayaram hn. J Med Chem. 1993 Jun 25;36(13):1855-9. doi: 10.1021/jm00065a008. J Med Chem. 1993. PMID: 8099976

10

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW. Chen L, et al. Among authors: jayaram hn. Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. doi: 10.1016/j.bmc.2010.06.081. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20650640

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