Gorman N - Search Results

1

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW. Uno S, et al. Among authors: gorman n. Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21. doi: 10.1016/j.taap.2004.01.014. Toxicol Appl Pharmacol. 2004. PMID: 15094312

2

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Dalton TP, Sinclair JF, Smith AG, Nebert DW. Sinclair PR, et al. Among authors: gorman n. Toxicol Appl Pharmacol. 2000 Jan 1;162(1):60-7. doi: 10.1006/taap.1999.8832. Toxicol Appl Pharmacol. 2000. PMID: 10631128 Free article.

3

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR. Gorman N, et al. Hepatology. 2002 Apr;35(4):912-21. doi: 10.1053/jhep.2002.32487. Hepatology. 2002. PMID: 11915039

4

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

Nichols RC, Cooper S, Trask HW, Gorman N, Dalton TP, Nebert DW, Sinclair JF, Sinclair PR. Nichols RC, et al. Among authors: gorman n. Biochem Pharmacol. 2003 Feb 15;65(4):545-50. doi: 10.1016/s0006-2952(02)01550-2. Biochem Pharmacol. 2003. PMID: 12566081

5

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.

Gorman N, Trask HS, Robinson SW, Sinclair JF, Gerhard GS, Smith AG, Sinclair PR. Gorman N, et al. Toxicol Appl Pharmacol. 2007 Jun 1;221(2):235-42. doi: 10.1016/j.taap.2007.03.007. Epub 2007 Mar 23. Toxicol Appl Pharmacol. 2007. PMID: 17466352

6

Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes.

Sinclair PR, Walton HS, Gorman N, Jacobs JM, Sinclair JF. Sinclair PR, et al. Among authors: gorman n. Toxicol Appl Pharmacol. 1997 Dec;147(2):171-9. doi: 10.1006/taap.1997.8273. Toxicol Appl Pharmacol. 1997. PMID: 9439713 Free article.

7

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

Sinclair PR, Gorman N, Dalton T, Walton HS, Bement WJ, Sinclair JF, Smith AG, Nebert DW. Sinclair PR, et al. Among authors: gorman n. Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):149-53. doi: 10.1042/bj3300149. Biochem J. 1998. PMID: 9461503 Free PMC article.

8

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair PR, Sinclair JF, Nebert DW, De Matteis F. Zaccaro C, et al. Among authors: gorman n. Biochem Pharmacol. 2001 Apr 1;61(7):843-9. doi: 10.1016/s0006-2952(01)00568-8. Biochem Pharmacol. 2001. PMID: 11274970

9

CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).

Gorman N, Walton HS, Sinclair JF, Sinclair PR. Gorman N, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):405-12. doi: 10.1016/s0742-8413(98)10059-2. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998. PMID: 9972481

10

Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.

Gorman N, Walton HS, Bement WJ, Honsinger CP, Szakacs JG, Sinclair JF, Sinclair PR. Gorman N, et al. Biochem Pharmacol. 1999 Jul 15;58(2):375-82. doi: 10.1016/s0006-2952(99)00088-x. Biochem Pharmacol. 1999. PMID: 10423181 Free article.

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