Purcell NH - Search Results

1

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.

Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JD. Lips DJ, et al. Among authors: purcell nh. Circulation. 2004 Apr 27;109(16):1938-41. doi: 10.1161/01.CIR.0000127126.73759.23. Epub 2004 Apr 19. Circulation. 2004. PMID: 15096454

2

Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?

Purcell NH, Molkentin JD. Purcell NH, et al. Circulation. 2003 Aug 12;108(6):638-40. doi: 10.1161/01.CIR.0000085362.40608.DD. Circulation. 2003. PMID: 12912791 No abstract available.

3

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.

Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD. Purcell NH, et al. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14074-9. doi: 10.1073/pnas.0610906104. Epub 2007 Aug 20. Proc Natl Acad Sci U S A. 2007. PMID: 17709754 Free PMC article.

4

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.

Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD. Purcell NH, et al. Mol Cell Biol. 2004 Feb;24(3):1081-95. doi: 10.1128/MCB.24.3.1081-1095.2004. Mol Cell Biol. 2004. PMID: 14729955 Free PMC article.

5

DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.

Maillet M, Purcell NH, Sargent MA, York AJ, Bueno OF, Molkentin JD. Maillet M, et al. Among authors: purcell nh. J Biol Chem. 2008 Nov 7;283(45):31246-55. doi: 10.1074/jbc.M806085200. Epub 2008 Aug 27. J Biol Chem. 2008. PMID: 18753132 Free PMC article.

6

RhoA protects the mouse heart against ischemia/reperfusion injury.

Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW 2nd, Brown JH. Xiang SY, et al. Among authors: purcell nh. J Clin Invest. 2011 Aug;121(8):3269-76. doi: 10.1172/JCI44371. Epub 2011 Jul 11. J Clin Invest. 2011. PMID: 21747165 Free PMC article.

7

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.

Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD. Baines CP, et al. Among authors: purcell nh. Nature. 2005 Mar 31;434(7033):658-62. doi: 10.1038/nature03434. Nature. 2005. PMID: 15800627

8

Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB.

Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. Ling H, et al. Among authors: purcell nh. Circ Res. 2013 Mar 15;112(6):935-44. doi: 10.1161/CIRCRESAHA.112.276915. Epub 2013 Feb 6. Circ Res. 2013. PMID: 23388157 Free PMC article.

9

APJ acts as a dual receptor in cardiac hypertrophy.

Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. Scimia MC, et al. Among authors: purcell nh. Nature. 2012 Aug 16;488(7411):394-8. doi: 10.1038/nature11263. Nature. 2012. PMID: 22810587 Free PMC article.

10

PHLPP-1 negatively regulates Akt activity and survival in the heart.

Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. Miyamoto S, et al. Among authors: purcell nh. Circ Res. 2010 Aug 20;107(4):476-84. doi: 10.1161/CIRCRESAHA.109.215020. Epub 2010 Jun 24. Circ Res. 2010. PMID: 20576936 Free PMC article.

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