Obst-Sander U - Search Results

1

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

Olsen J, Seiler P, Wagner B, Fischer H, Tschopp T, Obst-Sander U, Banner DW, Kansy M, Müller K, Diederich F. Olsen J, et al. Org Biomol Chem. 2004 May 7;2(9):1339-52. doi: 10.1039/b402515f. Epub 2004 Apr 14. Org Biomol Chem. 2004. PMID: 15105924

2

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.

Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F. Olsen JA, et al. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. doi: 10.1002/anie.200351268. Angew Chem Int Ed Engl. 2003. PMID: 12800172 No abstract available.

3

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.

Olsen JA, Banner DW, Seiler P, Wagner B, Tschopp T, Obst-Sander U, Kansy M, Müller K, Diederich F. Olsen JA, et al. Chembiochem. 2004 May 3;5(5):666-75. doi: 10.1002/cbic.200300907. Chembiochem. 2004. PMID: 15122639

4

Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.

Schweizer E, Hoffmann-Röder A, Olsen JA, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Schweizer E, et al. Among authors: obst sander u. Org Biomol Chem. 2006 Jun 21;4(12):2364-75. doi: 10.1039/b602585d. Epub 2006 May 10. Org Biomol Chem. 2006. PMID: 16763681

5

A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values.

Schweizer E, Hoffmann-Röder A, Schärer K, Olsen JA, Fäh C, Seiler P, Obst-Sander U, Wagner B, Kansy M, Diederich F. Schweizer E, et al. Among authors: obst sander u. ChemMedChem. 2006 Jun;1(6):611-21. doi: 10.1002/cmdc.200600015. ChemMedChem. 2006. PMID: 16892401

6

Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket.

Hoffmann-Röder A, Schweizer E, Egger J, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Hoffmann-Röder A, et al. Among authors: obst sander u. ChemMedChem. 2006 Nov;1(11):1205-15. doi: 10.1002/cmdc.200600124. ChemMedChem. 2006. PMID: 17001711

7

Fluorine in medicinal chemistry.

Böhm HJ, Banner D, Bendels S, Kansy M, Kuhn B, Müller K, Obst-Sander U, Stahl M. Böhm HJ, et al. Chembiochem. 2004 May 3;5(5):637-43. doi: 10.1002/cbic.200301023. Chembiochem. 2004. PMID: 15122635 Review.

8

Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand.

Schärer K, Morgenthaler M, Paulini R, Obst-Sander U, Banner DW, Schlatter D, Benz J, Stihle M, Diederich F. Schärer K, et al. Angew Chem Int Ed Engl. 2005 Jul 11;44(28):4400-4. doi: 10.1002/anie.200500883. Angew Chem Int Ed Engl. 2005. PMID: 15952226 No abstract available.

9

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.

Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lavé T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U. Groebke Zbinden K, et al. Among authors: obst sander u. Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. doi: 10.1016/j.bmc.2006.03.042. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621574

10

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.

Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T. Zbinden KG, et al. Among authors: obst sander u. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. doi: 10.1016/j.bmcl.2005.04.079. Epub 2005 Oct 4. Bioorg Med Chem Lett. 2005. PMID: 16213138

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