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Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T. Ogihara T, et al. Among authors: komuro i. Diabetologia. 2004 May;47(5):794-805. doi: 10.1007/s00125-004-1391-x. Epub 2004 May 1. Diabetologia. 2004. PMID: 15127200
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, Yazaki Y, Kadowaki T. Yamauchi T, et al. Among authors: komuro i. J Biol Chem. 1998 Jun 19;273(25):15719-26. doi: 10.1074/jbc.273.25.15719. J Biol Chem. 1998. PMID: 9624169 Free article.
Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression.
Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tsushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T. Yamauchi T, et al. Among authors: komuro i. Endocr J. 1998 Apr;45 Suppl:S27-31. doi: 10.1507/endocrj.45.suppl_s27. Endocr J. 1998. PMID: 9790226 Free article. Review.
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase.
Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T. Terauchi Y, et al. Among authors: komuro i. Nat Genet. 1999 Feb;21(2):230-5. doi: 10.1038/6023. Nat Genet. 1999. PMID: 9988280
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, Hayashi D, Hosoda T, Habara-Ohkubo A, Nakaoka T, Fujita T, Yazaki Y, Komuro I. Monzen K, et al. Among authors: komuro i. Mol Cell Biol. 1999 Oct;19(10):7096-105. doi: 10.1128/MCB.19.10.7096. Mol Cell Biol. 1999. PMID: 10490646 Free PMC article.
Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1.
Hiroi Y, Chen R, Sawa H, Hosoda T, Kudoh S, Kobayashi Y, Aburatani H, Nagashima K, Nagai R, Yazaki Y, Medof ME, Komuro I. Hiroi Y, et al. Among authors: komuro i. Am J Physiol Cell Physiol. 2000 Jul;279(1):C205-12. doi: 10.1152/ajpcell.2000.279.1.C205. Am J Physiol Cell Physiol. 2000. PMID: 10898732 Free article.
1,474 results