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Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T. Ogihara T, et al. Diabetologia. 2004 May;47(5):794-805. doi: 10.1007/s00125-004-1391-x. Epub 2004 May 1. Diabetologia. 2004. PMID: 15127200
Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.
Nawano M, Anai M, Funaki M, Kobayashi H, Kanda A, Fukushima Y, Inukai K, Ogihara T, Sakoda H, Onishi Y, Kikuchi M, Yazaki Y, Oka Y, Asano T. Nawano M, et al. Among authors: ogihara t. Metabolism. 1999 Oct;48(10):1248-55. doi: 10.1016/s0026-0495(99)90263-9. Metabolism. 1999. PMID: 10535386
MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.
Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Funaki M, Inukai K, Fukushima Y, Kikuchi M, Oka Y, Asano T. Fujishiro M, et al. Among authors: ogihara t. J Biol Chem. 2001 Jun 8;276(23):19800-6. doi: 10.1074/jbc.M101087200. Epub 2001 Feb 27. J Biol Chem. 2001. PMID: 11279172 Free article.
1,708 results