Fransen MF - Search Results

1

The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment.

den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. Among authors: fransen mf. J Immunol. 2004 May 15;172(10):6074-9. doi: 10.4049/jimmunol.172.10.6074. J Immunol. 2004. PMID: 15128791

2

Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance.

den Boer AT, Diehl L, van Mierlo GJ, van der Voort EI, Fransen MF, Krimpenfort P, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. Among authors: fransen mf. J Immunol. 2001 Sep 1;167(5):2522-8. doi: 10.4049/jimmunol.167.5.2522. J Immunol. 2001. PMID: 11509591

3

CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.

van Mierlo GJ, den Boer AT, Medema JP, van der Voort EI, Fransen MF, Offringa R, Melief CJ, Toes RE. van Mierlo GJ, et al. Among authors: fransen mf. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5561-6. doi: 10.1073/pnas.082107699. Epub 2002 Apr 2. Proc Natl Acad Sci U S A. 2002. PMID: 11929985 Free PMC article.

4

In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.

Diehl L, van Mierlo GJ, den Boer AT, van der Voort E, Fransen M, van Bostelen L, Krimpenfort P, Melief CJ, Mittler R, Toes RE, Offringa R. Diehl L, et al. J Immunol. 2002 Apr 15;168(8):3755-62. doi: 10.4049/jimmunol.168.8.3755. J Immunol. 2002. PMID: 11937526

5

Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

Boonman ZF, van Mierlo GJ, Fransen MF, Franken KL, Offringa R, Melief CJ, Jager MJ, Toes RE. Boonman ZF, et al. Among authors: fransen mf. J Immunol. 2004 Feb 1;172(3):1567-74. doi: 10.4049/jimmunol.172.3.1567. J Immunol. 2004. PMID: 14734736

6

Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication.

van Mierlo GJ, Boonman ZF, Dumortier HM, den Boer AT, Fransen MF, Nouta J, van der Voort EI, Offringa R, Toes RE, Melief CJ. van Mierlo GJ, et al. Among authors: fransen mf. J Immunol. 2004 Dec 1;173(11):6753-9. doi: 10.4049/jimmunol.173.11.6753. J Immunol. 2004. PMID: 15557168

7

CD4+ T cells are able to promote tumor growth through inhibition of tumor-specific CD8+ T-cell responses in tumor-bearing hosts.

den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE. den Boer AT, et al. Among authors: fransen mf. Cancer Res. 2005 Aug 1;65(15):6984-9. doi: 10.1158/0008-5472.CAN-04-3344. Cancer Res. 2005. PMID: 16061684

8

Maintenance of immune tolerance depends on normal tissue homeostasis.

Boonman ZF, van Mierlo GJ, Fransen MF, de Keizer RJ, Jager MJ, Melief CJ, Toes RE. Boonman ZF, et al. Among authors: fransen mf. J Immunol. 2005 Oct 1;175(7):4247-54. doi: 10.4049/jimmunol.175.7.4247. J Immunol. 2005. PMID: 16177064

9

Separate roles for antigen recognition and lymph node inflammation in CD8+ memory T cell formation.

Fransen MF, van Stipdonk MJ, Sluijter M, Schoenberger SP, Melief CJ, Offringa R. Fransen MF, et al. J Immunol. 2010 Sep 15;185(6):3167-73. doi: 10.4049/jimmunol.0904046. Epub 2010 Aug 9. J Immunol. 2010. PMID: 20696863 Free PMC article.

10

Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody.

Fransen MF, Sluijter M, Morreau H, Arens R, Melief CJ. Fransen MF, et al. Clin Cancer Res. 2011 Apr 15;17(8):2270-80. doi: 10.1158/1078-0432.CCR-10-2888. Epub 2011 Mar 9. Clin Cancer Res. 2011. PMID: 21389097

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