Effective therapy of metastatic ovarian cancer with an oncolytic herpes simplex virus incorporating two membrane fusion mechanisms.
Nakamori M, Fu X, Meng F, Jin A, Tao L, Bast RC Jr, Zhang X.
Nakamori M, et al. Among authors: fu x.
Clin Cancer Res. 2003 Jul;9(7):2727-33.
Clin Cancer Res. 2003.
PMID: 12855653
Incorporation of membrane fusion capability into an oncolytic HSV, either by screening for a syncytial HSV mutant after random mutagenesis or by inserting a hyperfusogenic glycoprotein from gibbon ape leukemia virus into the viral genome, can significantly enhance the antitumor e …
Incorporation of membrane fusion capability into an oncolytic HSV, either by screening for a syncytial HSV mutant after random mutagenesis o …