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Decreased nucleotide excision repair activity and alterations of topoisomerase IIalpha are associated with the in vivo resistance of a P388 leukemia subline to F11782, a novel catalytic inhibitor of topoisomerases I and II.
Kruczynski A, Barret JM, Van Hille B, Chansard N, Astruc J, Menon Y, Duchier C, Créancier L, Hill BT. Kruczynski A, et al. Among authors: hill bt. Clin Cancer Res. 2004 May 1;10(9):3156-68. doi: 10.1158/1078-0432.ccr-1305-2. Clin Cancer Res. 2004. PMID: 15131057
F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103.
Etiévant C, Kruczynski A, Barret JM, Perrin D, van Hille B, Guminski Y, Hill BT. Etiévant C, et al. Among authors: hill bt. Cancer Chemother Pharmacol. 2000;46(2):101-13. doi: 10.1007/s002800000133. Cancer Chemother Pharmacol. 2000. PMID: 10972479
415 results