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5Alpha-bile alcohols function as farnesoid X receptor antagonists.
Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M. Nishimaki-Mogami T, et al. Among authors: une m. Biochem Biophys Res Commun. 2006 Jan 6;339(1):386-91. doi: 10.1016/j.bbrc.2005.11.027. Epub 2005 Nov 14. Biochem Biophys Res Commun. 2006. PMID: 16300737
Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.
Teno N, Yamashita Y, Masuda A, Iguchi Y, Oda K, Fujimori K, Hiramoto T, Nishimaki-Mogami T, Une M, Gohda K. Teno N, et al. Among authors: une m. Bioorg Med Chem. 2019 Jun 1;27(11):2220-2227. doi: 10.1016/j.bmc.2019.04.029. Epub 2019 Apr 20. Bioorg Med Chem. 2019. PMID: 31029550
94 results