Okamoto K - Search Results

1

The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.

Okamoto K, Matsumoto K, Hille R, Eger BT, Pai EF, Nishino T. Okamoto K, et al. Proc Natl Acad Sci U S A. 2004 May 25;101(21):7931-6. doi: 10.1073/pnas.0400973101. Epub 2004 May 17. Proc Natl Acad Sci U S A. 2004. PMID: 15148401 Free PMC article.

2

Purification and characterization of multiple forms of rat liver xanthine oxidoreductase expressed in baculovirus-insect cell system.

Nishino T, Amaya Y, Kawamoto S, Kashima Y, Okamoto K, Nishino T. Nishino T, et al. Among authors: okamoto k. J Biochem. 2002 Oct;132(4):597-606. doi: 10.1093/oxfordjournals.jbchem.a003262. J Biochem. 2002. PMID: 12359075 Free article.

3

An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.

Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T. Okamoto K, et al. J Biol Chem. 2003 Jan 17;278(3):1848-55. doi: 10.1074/jbc.M208307200. Epub 2002 Nov 5. J Biol Chem. 2003. PMID: 12421831 Free article.

4

Resonance Raman studies on xanthine oxidase: observation of Mo(VI)-ligand vibrations.

Maiti NC, Tomita T, Kitagawa T, Okamoto K, Nishino T. Maiti NC, et al. Among authors: okamoto k. J Biol Inorg Chem. 2003 Feb;8(3):327-33. doi: 10.1007/s00775-002-0418-3. Epub 2002 Nov 22. J Biol Inorg Chem. 2003. PMID: 12589568

5

Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase.

Kuwabara Y, Nishino T, Okamoto K, Matsumura T, Eger BT, Pai EF, Nishino T. Kuwabara Y, et al. Among authors: okamoto k. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8170-5. doi: 10.1073/pnas.1431485100. Epub 2003 Jun 19. Proc Natl Acad Sci U S A. 2003. PMID: 12817083 Free PMC article.

6

[Molecular switching mechanism of xanthine oxidoreductase].

Okamoto K, Kuwabara Y, Nishino T, Nishino T. Okamoto K, et al. Tanpakushitsu Kakusan Koso. 2004 Apr;49(5):625-33. Tanpakushitsu Kakusan Koso. 2004. PMID: 15071893 Review. Japanese. No abstract available.

7

Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid]: a potent xanthine oxidoreductase inhibitor with hepatic excretion.

Fukunari A, Okamoto K, Nishino T, Eger BT, Pai EF, Kamezawa M, Yamada I, Kato N. Fukunari A, et al. Among authors: okamoto k. J Pharmacol Exp Ther. 2004 Nov;311(2):519-28. doi: 10.1124/jpet.104.070433. Epub 2004 Jun 9. J Pharmacol Exp Ther. 2004. PMID: 15190124

8

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.

Nishino T, Okamoto K, Kawaguchi Y, Hori H, Matsumura T, Eger BT, Pai EF, Nishino T. Nishino T, et al. Among authors: okamoto k. J Biol Chem. 2005 Jul 1;280(26):24888-94. doi: 10.1074/jbc.M501830200. Epub 2005 May 4. J Biol Chem. 2005. PMID: 15878860 Free article.

9

Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase.

Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T. Asai R, et al. Among authors: okamoto k. J Biochem. 2007 Apr;141(4):525-34. doi: 10.1093/jb/mvm054. Epub 2007 Feb 14. J Biochem. 2007. PMID: 17301076

10

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.

Yamaguchi Y, Matsumura T, Ichida K, Okamoto K, Nishino T. Yamaguchi Y, et al. Among authors: okamoto k. J Biochem. 2007 Apr;141(4):513-24. doi: 10.1093/jb/mvm053. Epub 2007 Feb 14. J Biochem. 2007. PMID: 17301077

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