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Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
Walker SS, Xu Y, Triantafyllou I, Waldman MF, Mendrick C, Brown N, Mann P, Chau A, Patel R, Bauman N, Norris C, Antonacci B, Gurnani M, Cacciapuoti A, McNicholas PM, Wainhaus S, Herr RJ, Kuang R, Aslanian RG, Ting PC, Black TA. Walker SS, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5099-106. doi: 10.1128/AAC.00432-11. Epub 2011 Aug 15. Antimicrob Agents Chemother. 2011. PMID: 21844320 Free PMC article.
Changes in susceptibility to posaconazole in clinical isolates of Candida albicans.
Li X, Brown N, Chau AS, López-Ribot JL, Ruesga MT, Quindos G, Mendrick CA, Hare RS, Loebenberg D, DiDomenico B, McNicholas PM. Li X, et al. Among authors: chau as. J Antimicrob Chemother. 2004 Jan;53(1):74-80. doi: 10.1093/jac/dkh027. Epub 2003 Dec 4. J Antimicrob Chemother. 2004. PMID: 14657086
Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.
Xiao L, Madison V, Chau AS, Loebenberg D, Palermo RE, McNicholas PM. Xiao L, et al. Among authors: chau as. Antimicrob Agents Chemother. 2004 Feb;48(2):568-74. doi: 10.1128/AAC.48.2.568-574.2004. Antimicrob Agents Chemother. 2004. PMID: 14742211 Free PMC article.
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Munayyer HK, Mann PA, Chau AS, Yarosh-Tomaine T, Greene JR, Hare RS, Heimark L, Palermo RE, Loebenberg D, McNicholas PM. Munayyer HK, et al. Among authors: chau as. Antimicrob Agents Chemother. 2004 Oct;48(10):3690-6. doi: 10.1128/AAC.48.10.3690-3696.2004. Antimicrob Agents Chemother. 2004. PMID: 15388421 Free PMC article.
EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance.
Mann PA, Xiong L, Mankin AS, Chau AS, Mendrick CA, Najarian DJ, Cramer CA, Loebenberg D, Coates E, Murgolo NJ, Aarestrup FM, Goering RV, Black TA, Hare RS, McNicholas PM. Mann PA, et al. Among authors: chau as. Mol Microbiol. 2001 Sep;41(6):1349-56. doi: 10.1046/j.1365-2958.2001.02602.x. Mol Microbiol. 2001. PMID: 11580839 Free article.
70 results